Zgura Irina, Enculescu Monica, Istrate Cosmin, Negrea Raluca, Bacalum Mihaela, Nedelcu Liviu, Barbinta-Patrascu Marcela Elisabeta
National Institute of Materials Physics, Atomistilor 405A, 077125 Magurele, Romania.
Horia Hulubei National Institute for Physics and Nuclear Engineering (IFIN-HH), Department of Life and Environmental Physics, 077125 Bucharest-Magurele, Romania.
Nanomaterials (Basel). 2020 Oct 28;10(11):2146. doi: 10.3390/nano10112146.
In this work, the metal and semiconducting nanoparticles (AgNPs, ZnONPs and AgZnONPs) were phyto-synthesized using aqueous vegetal extracts from: L. (cloves) and L. (mandarin) peels. The morphological, structural, compositional, optical and biological properties (antibacterial activity, and cytotoxicity) of the prepared composites were investigated. The most effective sample proved to be AgZnONPs, derived from cloves, with a minimum inhibitory concentration (MIC) value of 0.11 mg/mL and a minimum bactericidal concentration (MBC) value of 2.68 mg/mL. All the other three composites inhibited bacterial growth at a concentration between 0.25 mg/mL and 0.37 mg/mL, with a bactericidal concentration between 3 mg/mL and 4 mg/mL. The obtained composites presented biocidal activity against , and biocompatibility (on human fibroblast BJ cells) and did not damage the human red blood cells. Additionally, an important result is that the presence of silver in composite materials improved the bactericidal action of these nanomaterials against the most common nosocomial pathogen, .
在本研究中，使用来自丁香和橘子皮的植物水提取物对金属和半导体纳米颗粒（AgNP、ZnONP和AgZnONP）进行了植物合成。对制备的复合材料的形态、结构、成分、光学和生物学性质（抗菌活性和细胞毒性）进行了研究。最有效的样品是源自丁香的AgZnONP，其最低抑菌浓度（MIC）值为0.11mg/mL，最低杀菌浓度（MBC）值为2.68mg/mL。其他三种复合材料在浓度为0.25mg/mL至0.37mg/mL之间抑制细菌生长，杀菌浓度在3mg/mL至4mg/mL之间。所获得的复合材料对[具体细菌名称]具有杀菌活性，对人成纤维细胞BJ细胞具有生物相容性，并且不会损伤人类红细胞。此外，一个重要的结果是复合材料中银的存在提高了这些纳米材料对最常见的医院病原体[具体细菌名称]的杀菌作用。
