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ZnO-NPs 嵌入可生物降解的硫醇化绷带用于术后手术部位感染：体外和体内评价。

ZnO-NPs embedded biodegradable thiolated bandage for postoperative surgical site infection: In vitro and in vivo evaluation.

机构信息

Department of Pharmacy, Faculty of Biological Sciences, Quaid-i-Azam University, Islamabad, Pakistan.

Riphah Institute of Pharmaceutical Sciences (RIPS), Riphah International University, Lahore Campus, Lahore, Pakistan.

出版信息

PLoS One. 2019 Jun 6;14(6):e0217079. doi: 10.1371/journal.pone.0217079. eCollection 2019.

DOI:10.1371/journal.pone.0217079
PMID:31170179
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC6553718/
Abstract

Post-operative surgical site infections (SSI) present a serious threat and may lead to complications. Currently available dressings for SSI lack mucoadhesion, safety, efficacy and most importantly patient compliance. We aimed to address these concerns by developing a bioactive thiolated chitosan-alginate bandage embedded with zinc oxide nanoparticles (ZnO-NPs) for localized topical treatment of SSI. The FTIR, XRD, DSC and TGA of bandage confirmed the compatibility of ingredients and modifications made. The porosity, swelling index and lysozyme degradation showed good properties for wound healing and biodegradation. Moreover, in-vitro antibacterial activity showed higher bactericidal effect as compared to ZnO-NPs free bandage. In-vivo wound healing in murine model showed significant improved tissue generation and speedy wound healing as compared to positive and negative controls. Over all, thiolated bandage showed potential as an advanced therapeutic agent for treating surgical site infections, meeting the required features of an ideal surgical dressing.

摘要

术后手术部位感染（SSI）是一种严重的威胁，并可能导致并发症。目前用于 SSI 的敷料缺乏粘膜粘附性、安全性、功效，最重要的是缺乏患者依从性。我们旨在通过开发一种带有氧化锌纳米粒子（ZnO-NPs）的生物活性硫代壳聚糖-海藻酸盐绷带来解决这些问题，用于 SSI 的局部局部治疗。绷带的 FTIR、XRD、DSC 和 TGA 证实了成分的相容性和所做的改性。多孔性、溶胀指数和溶菌酶降解显示出良好的伤口愈合和生物降解性能。此外，体外抗菌活性显示出比无 ZnO-NPs 绷带更高的杀菌效果。在小鼠模型中的体内伤口愈合研究表明，与阳性和阴性对照组相比，组织生成和伤口愈合速度有显著改善。总的来说，硫代绷带作为一种治疗手术部位感染的先进治疗剂具有潜力，满足理想手术敷料的所需特性。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/6db9/6553718/25e61caca794/pone.0217079.g007.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/6db9/6553718/a4e908a45138/pone.0217079.g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/6db9/6553718/aafebf2f620a/pone.0217079.g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/6db9/6553718/36ca850bbff2/pone.0217079.g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/6db9/6553718/569a60659f9a/pone.0217079.g004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/6db9/6553718/50fdfd21c14d/pone.0217079.g005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/6db9/6553718/ddfb2a536eb5/pone.0217079.g006.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/6db9/6553718/25e61caca794/pone.0217079.g007.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/6db9/6553718/a4e908a45138/pone.0217079.g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/6db9/6553718/aafebf2f620a/pone.0217079.g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/6db9/6553718/36ca850bbff2/pone.0217079.g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/6db9/6553718/569a60659f9a/pone.0217079.g004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/6db9/6553718/50fdfd21c14d/pone.0217079.g005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/6db9/6553718/ddfb2a536eb5/pone.0217079.g006.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/6db9/6553718/25e61caca794/pone.0217079.g007.jpg

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