鼠伤寒沙门氏菌组氨酸调节突变体中tRNA的生物合成
Biosynthesis of tRNA in histidine regulatory mutants of Salmonella typhimurium.
作者信息
Bossi L, Cortese R
出版信息
Nucleic Acids Res. 1977 Jun;4(6):1945-56. doi: 10.1093/nar/4.6.1945.
Abstract
HisU mutants of Salmonella typhimurium are depressed in the histidine operon since they have lower intracellular concentration of histidyl-tRNAHis. In this paper we present evidences showing that a strain carrying a hisU mutation (hisUl206) is altered in a nucleolytic enzyme involved in tRNA maturation process. The analysis of several hisU mutants indicates that hisU region of bacterial genome may account for more than one function involved in tRNA biosynthesis.
摘要
鼠伤寒沙门氏菌的HisU突变体在组氨酸操纵子中受到抑制，因为它们细胞内组氨酰 - tRNAHis的浓度较低。在本文中，我们提供证据表明，携带hisU突变（hisU1206）的菌株在参与tRNA成熟过程的一种核酸酶中发生了改变。对多个hisU突变体的分析表明，细菌基因组的hisU区域可能参与tRNA生物合成的不止一种功能。
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