• 文献检索
  • 文档翻译
  • 深度研究
  • 学术资讯
  • Suppr Zotero 插件Zotero 插件
  • 邀请有礼
  • 套餐&价格
  • 历史记录
应用&插件
Suppr Zotero 插件Zotero 插件浏览器插件Mac 客户端Windows 客户端微信小程序
定价
高级版会员购买积分包购买API积分包
服务
文献检索文档翻译深度研究API 文档MCP 服务
关于我们
关于 Suppr公司介绍联系我们用户协议隐私条款
关注我们

Suppr 超能文献

核心技术专利：CN118964589B侵权必究
粤ICP备2023148730 号-1Suppr @ 2026

文献检索

告别复杂PubMed语法，用中文像聊天一样搜索，搜遍4000万医学文献。AI智能推荐，让科研检索更轻松。

立即免费搜索

文件翻译

保留排版，准确专业，支持PDF/Word/PPT等文件格式，支持 12+语言互译。

免费翻译文档

深度研究

AI帮你快速写综述，25分钟生成高质量综述，智能提取关键信息，辅助科研写作。

立即免费体验

鼠伤寒沙门氏菌组氨酸调节突变体中tRNA的生物合成

Biosynthesis of tRNA in histidine regulatory mutants of Salmonella typhimurium.

作者信息

Bossi L, Cortese R

出版信息

Nucleic Acids Res. 1977 Jun;4(6):1945-56. doi: 10.1093/nar/4.6.1945.

DOI:10.1093/nar/4.6.1945
PMID:331266
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC342533/
Abstract

HisU mutants of Salmonella typhimurium are depressed in the histidine operon since they have lower intracellular concentration of histidyl-tRNAHis. In this paper we present evidences showing that a strain carrying a hisU mutation (hisUl206) is altered in a nucleolytic enzyme involved in tRNA maturation process. The analysis of several hisU mutants indicates that hisU region of bacterial genome may account for more than one function involved in tRNA biosynthesis.

摘要

鼠伤寒沙门氏菌的HisU突变体在组氨酸操纵子中受到抑制，因为它们细胞内组氨酰 - tRNAHis的浓度较低。在本文中，我们提供证据表明，携带hisU突变（hisU1206）的菌株在参与tRNA成熟过程的一种核酸酶中发生了改变。对多个hisU突变体的分析表明，细菌基因组的hisU区域可能参与tRNA生物合成的不止一种功能。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/4029/342533/04ea0b6af6f1/nar00479-0254-a.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/4029/342533/b74170652df2/nar00479-0249-a.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/4029/342533/01cc771e675a/nar00479-0251-a.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/4029/342533/39434e1ee95b/nar00479-0252-a.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/4029/342533/04ea0b6af6f1/nar00479-0254-a.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/4029/342533/b74170652df2/nar00479-0249-a.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/4029/342533/01cc771e675a/nar00479-0251-a.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/4029/342533/39434e1ee95b/nar00479-0252-a.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/4029/342533/04ea0b6af6f1/nar00479-0254-a.jpg

相似文献

1
Biosynthesis of tRNA in histidine regulatory mutants of Salmonella typhimurium.鼠伤寒沙门氏菌组氨酸调节突变体中tRNA的生物合成
Nucleic Acids Res. 1977 Jun;4(6):1945-56. doi: 10.1093/nar/4.6.1945.
2
Characterization of a Salmonella typhimurium hisU mutant defective in tRNA precursor processing.鼠伤寒沙门氏菌hisU突变体在tRNA前体加工方面存在缺陷的特性分析。
J Bacteriol. 1978 May;134(2):612-20. doi: 10.1128/jb.134.2.612-620.1978.
3
Defective in vitro binding of histidyl-transfer ribonucleic acid to feedback resistant phosphoribosyl transferase of Salmonella typhimurium.组氨酰转运核糖核酸与鼠伤寒沙门氏菌反馈抗性磷酸核糖转移酶的体外结合存在缺陷。
Nucleic Acids Res. 1974 Jul;1(7):881-8. doi: 10.1093/nar/1.7.881.
4
Histidine regulatory mutants in Salmonella typhimurium 3. A class of regulatory mutants deficient in tRNA for histidine.鼠伤寒沙门氏菌中的组氨酸调节突变体3. 一类组氨酸tRNA缺乏的调节突变体。
J Mol Biol. 1966 Dec 28;22(2):335-47. doi: 10.1016/0022-2836(66)90136-7.
5
Histidine regulatory mutants in Salmonella typhimurium II. Histidine regulatory mutants having altered histidyl-tRNA synthetase.鼠伤寒沙门氏菌中的组氨酸调节突变体II。具有改变的组氨酰-tRNA合成酶的组氨酸调节突变体。
J Mol Biol. 1966 Dec 28;22(2):325-33. doi: 10.1016/0022-2836(66)90135-5.
6
Pleiotropy of hisT mutants blocked in pseudouridine synthesis in tRNA: leucine and isoleucine-valine operons.在tRNA假尿苷合成中受阻的hisT突变体的多效性：亮氨酸和异亮氨酸 - 缬氨酸操纵子。
Proc Natl Acad Sci U S A. 1974 May;71(5):1857-61. doi: 10.1073/pnas.71.5.1857.
7
Gene expression of the histidine operon.组氨酸操纵子的基因表达。
Acta Microbiol Acad Sci Hung. 1976;23(2):151-9.
8
Histidine regulation in Salmonella typhimurium. IX. Histidine transfer ribonucleic acid of the regulatory mutants.鼠伤寒沙门氏菌中的组氨酸调控。IX. 调控突变体的组氨酸转移核糖核酸
J Biol Chem. 1972 Feb 25;247(4):1080-8.
9
Role of histidine transfer ribonucleic acid in regulation of synthesis of histidyl-transfer ribonucleic acid synthetase of Salmonella typhimurium.组氨酸转移核糖核酸在鼠伤寒沙门氏菌组氨酰转移核糖核酸合成酶合成调控中的作用。
J Bacteriol. 1972 Feb;109(2):505-11. doi: 10.1128/jb.109.2.505-511.1972.
10
Histidine regulation in salmonella typhimurium. XIV. Interaction of the histidyl transfer ribonucleic acid synthetase with histidine transfer ribonucleic acid.鼠伤寒沙门氏菌中的组氨酸调节。十四。组氨酰转移核糖核酸合成酶与组氨酸转移核糖核酸的相互作用。
J Biol Chem. 1972 Jul 10;247(13):4333-9.

引用本文的文献

1
Histidine operon deattenuation in dnaA mutants of Salmonella typhimurium correlates with a decrease in the gene dosage ratio between tRNA(His) and histidine biosynthetic loci.鼠伤寒沙门氏菌dnaA突变体中组氨酸操纵子的去衰减作用与tRNA(His)和组氨酸生物合成基因座之间基因剂量比的降低相关。
J Bacteriol. 1999 May;181(9):2938-41. doi: 10.1128/JB.181.9.2938-2941.1999.
2
Model for regulation of the histidine operon of Salmonella.沙门氏菌组氨酸操纵子调控模型。
Proc Natl Acad Sci U S A. 1980 Jan;77(1):508-12. doi: 10.1073/pnas.77.1.508.
3
The hisR locus of Salmonella: nucleotide sequence and expression.

本文引用的文献

1
Temperature sensitive mutants of Escherichia coli for tRNA synthesis.用于tRNA合成的大肠杆菌温度敏感突变体。
Nucleic Acids Res. 1974 Mar;1(3):355-71. doi: 10.1093/nar/1.3.355.
2
Resolution of multiple ribonucleic acid species by polyacrylamide gel electrophoresis.通过聚丙烯酰胺凝胶电泳分离多种核糖核酸种类
Biochemistry. 1967 Jun;6(6):1818-27. doi: 10.1021/bi00858a033.
3
Histidine regulatory mutants in Salmonella typhimurium 3. A class of regulatory mutants deficient in tRNA for histidine.鼠伤寒沙门氏菌中的组氨酸调节突变体3. 一类组氨酸tRNA缺乏的调节突变体。
沙门氏菌的hisR基因座：核苷酸序列与表达
Mol Gen Genet. 1983;192(1-2):163-70. doi: 10.1007/BF00327662.
4
Characterization of a cold-sensitive hisW mutant of Salmonella typhimurium.鼠伤寒沙门氏菌冷敏感 hisW 突变体的特性分析
J Bacteriol. 1982 Aug;151(2):867-78. doi: 10.1128/jb.151.2.867-878.1982.
5
his operons of Escherichia coli and Salmonella typhimurium are regulated by DNA supercoiling.大肠杆菌和鼠伤寒沙门氏菌的这些操纵子受DNA超螺旋调控。
Proc Natl Acad Sci U S A. 1987 Jan;84(2):517-21. doi: 10.1073/pnas.84.2.517.
6
Common sequence determinants of the response of a prokaryotic promoter to DNA bending and supercoiling.原核生物启动子对DNA弯曲和超螺旋响应的常见序列决定因素。
EMBO J. 1991 Apr;10(4):941-9. doi: 10.1002/j.1460-2075.1991.tb08028.x.
7
Linkage map of Salmonella typhimurium, edition V.鼠伤寒沙门氏菌连锁图谱，第五版
Microbiol Rev. 1978 Jun;42(2):471-519. doi: 10.1128/mr.42.2.471-519.1978.
8
Characterization of a Salmonella typhimurium hisU mutant defective in tRNA precursor processing.鼠伤寒沙门氏菌hisU突变体在tRNA前体加工方面存在缺陷的特性分析。
J Bacteriol. 1978 May;134(2):612-20. doi: 10.1128/jb.134.2.612-620.1978.
J Mol Biol. 1966 Dec 28;22(2):335-47. doi: 10.1016/0022-2836(66)90136-7.
4
A film detection method for tritium-labelled proteins and nucleic acids in polyacrylamide gels.一种用于检测聚丙烯酰胺凝胶中氚标记蛋白质和核酸的胶片检测方法。
Eur J Biochem. 1974 Jul 1;46(1):83-8. doi: 10.1111/j.1432-1033.1974.tb03599.x.
5
Biosynthesis of pseudouridine in transfer ribonucleic acid.转运核糖核酸中假尿苷的生物合成
J Biol Chem. 1974 Feb 25;249(4):1103-8.
6
Mutants of Escherichia coli thermosensitive for the synthesis of transfer RNA.对转运RNA合成具有温度敏感性的大肠杆菌突变体。
Proc Natl Acad Sci U S A. 1973 Jul;70(7):2091-5. doi: 10.1073/pnas.70.7.2091.
7
Small ribonucleic acids of Escherichia coli. I. Characterization by polyacrylamide gel electrophoresis and fingerprint analysis.大肠杆菌的小核糖核酸。I. 通过聚丙烯酰胺凝胶电泳和指纹分析进行表征
J Biol Chem. 1973 Jul 25;248(14):5024-32.
8
Purification and properties of a specific Escherichia coli ribonuclease which cleaves a tyrosine transfer ribonucleic acid presursor.一种可切割酪氨酸转移核糖核酸前体的特异性大肠杆菌核糖核酸酶的纯化及性质
J Biol Chem. 1972 Aug 25;247(16):5243-51.
9
Mutant tRNA His ineffective in repression and lacking two pseudouridine modifications.突变型组氨酸转运RNA在抑制方面无效且缺乏两个假尿苷修饰。
Nat New Biol. 1972 Jul 19;238(81):72-4. doi: 10.1038/newbio238072a0.
10
Histidine regulation in Salmonella typhimurium. IX. Histidine transfer ribonucleic acid of the regulatory mutants.鼠伤寒沙门氏菌中的组氨酸调控。IX. 调控突变体的组氨酸转移核糖核酸
J Biol Chem. 1972 Feb 25;247(4):1080-8.