组氨酸转移核糖核酸在鼠伤寒沙门氏菌组氨酰转移核糖核酸合成酶合成调控中的作用。
Role of histidine transfer ribonucleic acid in regulation of synthesis of histidyl-transfer ribonucleic acid synthetase of Salmonella typhimurium.
作者信息
McGinnis E, Williams L S
出版信息
J Bacteriol. 1972 Feb;109(2):505-11. doi: 10.1128/jb.109.2.505-511.1972.
Abstract
The role of histidine transfer ribonucleic acid (tRNA) in repression of synthesis of histidyl-tRNA synthetase was examined in two strains of Salmonella typhimurium, one of which was a histidine tRNA (hisR) mutant possessing 52% of the wild-type (hisR(+)) histidine tRNA and a derepressed level of the histidine biosynthetic enzymes during histidine-unrestricted growth. Histidine-restricted growth caused a derepression of the rate of formation of histidyl-tRNA synthetase in both strains. In the case of the wild-type strain, addition of histidine to the derepressed culture caused a repression of synthesis of histidyl-tRNA synthetase for at least one generation of growth. In contrast, when histidine was restored to the derepressed hisR mutant culture, synthesis of histidyl-tRNA synthetase was continued at the initial derepressed rate. These results suggest that histidine must be attached to histidine tRNA for repression of synthesis of histidyl-tRNA synthetase.
摘要
在两株鼠伤寒沙门氏菌中研究了组氨酸转移核糖核酸（tRNA）在抑制组氨酰-tRNA合成酶合成中的作用。其中一株是组氨酸tRNA（hisR）突变体，其具有野生型（hisR(+)）组氨酸tRNA的52%，并且在组氨酸不受限制生长期间组氨酸生物合成酶处于去阻遏水平。组氨酸限制生长导致两株菌株中组氨酰-tRNA合成酶形成速率的去阻遏。对于野生型菌株，向去阻遏培养物中添加组氨酸会导致组氨酰-tRNA合成酶合成的抑制至少持续一代生长。相反，当向去阻遏的hisR突变体培养物中恢复组氨酸时，组氨酰-tRNA合成酶的合成以初始去阻遏速率继续。这些结果表明，组氨酸必须连接到组氨酸tRNA上才能抑制组氨酰-tRNA合成酶的合成。
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