Miyamoto M, Sakamoto K
Dept. of Radiation Research, Tohoku Univ. School of Med.
Gan No Rinsho. 1987 Aug;33(10):1211-20.
The effect of low dose (0.05-1.0 Gy) of total body irradiation (TBI) on non-tumor bearing and tumor bearing mice were investigated. Mice received TBI of 0.1 Gy during 6-12 hours before tumor cell inoculation demonstrated to need larger number of tumor cells (approximately 2.5 times) for 50 per cent tumor incidence, compared to recipient mice not to receive TBI. On the other hand, in tumor bearing mice given 0.1 Gy of TBI only tumor cell killing effect was not detected, however enhancement of tumor cell killing effect and prolonged growth delay were observed when tumor bearing mice were treated with 0.1 Gy of TBI in combined with local irradiation on tumors, especially cell killing effect was remarkable in dose range over 6 Gy of local exposure. The mechanism of the effect of 0.1 Gy TBI is considered to be host mediated reactions from the other our experimental results.
研究了低剂量（0.05 - 1.0 Gy）全身照射（TBI）对无瘤和荷瘤小鼠的影响。在肿瘤细胞接种前6 - 12小时接受0.1 Gy TBI的小鼠与未接受TBI的受体小鼠相比，50%肿瘤发生率所需的肿瘤细胞数量更多（约2.5倍）。另一方面，在接受0.1 Gy TBI的荷瘤小鼠中，未检测到仅肿瘤细胞杀伤作用，然而，当荷瘤小鼠接受0.1 Gy TBI并联合肿瘤局部照射时，观察到肿瘤细胞杀伤作用增强和生长延迟延长，特别是在局部照射剂量超过6 Gy的剂量范围内，细胞杀伤作用显著。根据我们的其他实验结果，0.1 Gy TBI作用的机制被认为是宿主介导的反应。
