Sakamoto K, Miyamoto M, Watabe N, Takai Y
Dept. of Radiology, Tohoku Univ. School of Med.
Gan No Rinsho. 1987 Oct;33(13):1633-8.
Total body irradiation of 10 rad showed an enhancement effect on tumor cell killing when given 12 hours before local tumor irradiation. In order to clarify the mechanism of this kind of effect, some immunological studies were performed using several immunological procedures, and the results suggested that 10 rad of total body irradiation caused increasing tumor immunity in irradiated tumor bearing mice. Clinical trials in some patients with advanced tumors are now being undertaken on the basis of these experimental data, and the effect of total body irradiation tumor control appears promising although it is too early to draw conclusions.
全身照射10拉德，若在局部肿瘤照射前12小时进行，对肿瘤细胞杀伤显示出增强作用。为阐明这种效应的机制，采用多种免疫程序进行了一些免疫学研究，结果表明10拉德的全身照射可增强受照射荷瘤小鼠的肿瘤免疫力。目前正基于这些实验数据对一些晚期肿瘤患者进行临床试验，尽管现在得出结论还为时过早，但全身照射对肿瘤控制的效果似乎很有前景。
