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低剂量区域辐射致癌的剂量-反应关系。

Dose-response relationship for radiation carcinogenesis in the low-dose region.

作者信息

Cohen B L

机构信息

University of Pittsburgh, PA 15260.

出版信息

Int Arch Occup Environ Health. 1994;66(2):71-5. doi: 10.1007/BF00383360.

DOI:10.1007/BF00383360
PMID:7806399
Abstract

Evidence that low-level radiation substantially enhances the effectiveness of repair mechanisms is summarized. This finding destroys the theoretical basis (there is no other basis) for use of a linear-no threshold dose-response relationship to estimate the cancer risk of exposure to low-level radiation. Such a methodology will exaggerate the risk. This conclusion is further supported by epidemiological evidence and by studies of the effects of radon exposure in the home, which are reviewed.

摘要

低水平辐射能显著增强修复机制有效性的证据已被总结。这一发现摧毁了使用线性无阈值剂量反应关系来估计低水平辐射致癌风险的理论基础(不存在其他基础)。这种方法会夸大风险。这一结论得到了流行病学证据以及家庭中氡暴露影响研究的进一步支持,这些研究将进行综述。

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2
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Health Impacts of Low-Dose Ionizing Radiation: Current Scientific Debates and Regulatory Issues.

本文引用的文献

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RADIOSENSITIVITY OF THE IMMUNE RESPONSE TO SHEEP RED CELLS IN THE MOUSE, AS MEASURED BY THE HEMOLYTIC PLAQUE METHOD.用溶血空斑法测定小鼠对绵羊红细胞免疫反应的放射敏感性。
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Residential radon exposure and lung cancer in Sweden.瑞典的住宅氡暴露与肺癌
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Lung cancer: epidemiology, etiology, and prevention.肺癌:流行病学、病因学和预防。
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6
Radiation hormesis: historical perspective and implications for low-dose cancer risk assessment.辐射兴奋效应:历史透视及其对低剂量癌症风险评估的意义。
Dose Response. 2010 Jan 18;8(2):172-91. doi: 10.2203/dose-response.09-037.Vaiserman.
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A rebuttal to chiropractic radiologists' view of the 50-year-old, linear-no-threshold radiation risk model.对脊椎按摩疗法放射科医生关于有50年历史的线性无阈辐射风险模型观点的反驳。
J Can Chiropr Assoc. 2006 Sep;50(3):172-81.
8
Occupational levels of radiation exposure induce surface expression of interleukin-2 receptors in stimulated human peripheral blood lymphocytes.职业性辐射暴露水平可诱导受刺激的人外周血淋巴细胞表面白细胞介素-2受体的表达。
Radiat Environ Biophys. 1996 May;35(2):89-93. doi: 10.1007/BF02434030.
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4
Induction of an adaptive response to dominant lethality and to chromosome damage of mouse germ cells by low dose radiation.低剂量辐射诱导小鼠生殖细胞对显性致死和染色体损伤的适应性反应。
Mutat Res. 1993 Dec;303(4):157-61. doi: 10.1016/0165-7992(93)90017-p.
5
Low-dose radiation-induced adaptive response in bone marrow cells of mice.低剂量辐射诱导小鼠骨髓细胞的适应性反应。
Mutat Res. 1993 Jun;302(2):83-9. doi: 10.1016/0165-7992(93)90008-j.
6
Cultured mouse SR-1 cells exposed to low dose of gamma-rays become less susceptible to the induction of mutagenesis by radiation as well as bleomycin.暴露于低剂量伽马射线的培养小鼠SR-1细胞对辐射和博来霉素诱导的诱变作用的敏感性降低。
Mutagenesis. 1993 Mar;8(2):109-11. doi: 10.1093/mutage/8.2.109.
7
Exposure of human lymphocytes to ionizing radiation reduces mutagenesis by subsequent ionizing radiation.将人类淋巴细胞暴露于电离辐射下可减少后续电离辐射导致的诱变作用。
Mutat Res. 1986 Dec;164(6):347-51. doi: 10.1016/0165-1161(86)90027-0.
8
Low dose irradiation permits immunization of A/J mice with subimmunogenic numbers of SaI cells.低剂量照射可使A/J小鼠用亚免疫原数量的SaI细胞进行免疫。
Br J Cancer. 1986 Sep;54(3):505-9. doi: 10.1038/bjc.1986.204.
9
[Anti-tumor effect of total body irradiation of low doses on WHT/Ht mice].[低剂量全身照射对WHT/Ht小鼠的抗肿瘤作用]
Gan No Rinsho. 1987 Aug;33(10):1211-20.
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Very low doses of X-rays can cause human lymphocytes to become less susceptible to ionizing radiation.
Mutagenesis. 1987 Mar;2(2):95-6. doi: 10.1093/mutage/2.2.95.