Reconstructive Surgery & Regenerative Medicine Research Group, Institute Of Life Sciences, Swansea University Medical School, Swansea, UK; Welsh Centre for Burns and Plastics, Morriston Hospital, Swansea, UK.
Department of Plastic, Reconstructive and Hand Surgery, Catharina Hospital, Eindhoven, the Netherlands; Patient-Reported Outcomes, Value and Experience (PROVE) Centre, Department of Surgery, Brigham and Women's Hospital, Boston, MA, USA; Department of Surgery, Harvard Medical School, Boston, MA, USA.
J Plast Reconstr Aesthet Surg. 2021 Mar;74(3):615-624. doi: 10.1016/j.bjps.2020.09.005. Epub 2020 Oct 9.
Facial skin cancer is common, and its treatment affects patient's health-related quality of life (HRQoL), as demonstrated by patient-reported outcome measures (PROMs). In this study, we anglicise and validate the novel FACE-Q Skin Cancer Module for the UK population. Anglicisation of the FACE-Q Skin Cancer Module followed international guidance for cross-cultural adaptation. Cognitive interviews were performed, producing a reconciled and harmonised version for validation. Patients undergoing facial skin cancer excision were prospectively recruited and asked to complete the anglicised FACE-Q Skin Cancer Module, along with the Skin Cancer Index (SCI) and European Quality of Life-Five Dimensions (ED-5D) questionnaire, pre-operatively and 6-8 weeks post-operatively. Data were analysed using classical test theory. Ethical approval was obtained (REC: 16/WM/0445). One hundred and ten patients were recruited between August 2017 and July 2018. Internal consistency was high (Cronbach's alpha 0.867-0.967). All subscales had a single-factor solution using principal component analysis. Construct validity, as measured between the FACE-Q subscales and SCI subscales, was good, with >75% of a priori predictions confirmed. Pearson's r for item-total correlation was >0.80 for several items, and significant ceiling effects are shown in 7 of the 10 subscales, suggesting some item redundancy. The UK version of this well-designed PROM demonstrates good face and construct validity. There is however a degree of redundancy within the scales, and further work using Rasch analysis on a larger sample will help address this.
面部皮肤癌很常见，其治疗会影响患者的健康相关生活质量（HRQoL），这一点可以通过患者报告的结果测量（PROMs）来证明。在这项研究中，我们对英国人群进行了新型 FACE-Q 皮肤癌模块的英文转化和验证。FACE-Q 皮肤癌模块的英文转化遵循了跨文化适应的国际指导原则。进行了认知访谈，得出了一个协调一致的版本进行验证。前瞻性招募了接受面部皮肤癌切除术的患者，并要求他们在术前和术后 6-8 周分别填写英文转化的 FACE-Q 皮肤癌模块、皮肤癌指数（SCI）和欧洲生活质量五维问卷（ED-5D）。使用经典测试理论进行数据分析。本研究获得了伦理批准（REC：16/WM/0445）。2017 年 8 月至 2018 年 7 月期间，共招募了 110 名患者。内部一致性很高（Cronbach's alpha 0.867-0.967）。使用主成分分析，所有子量表都具有单一因素解决方案。结构有效性，如通过 FACE-Q 子量表和 SCI 子量表之间的测量，很好，超过 75%的先验预测得到了证实。对于几个项目，项目-总分相关的 Pearson's r 大于 0.80，并且在 10 个子量表中的 7 个中显示出显著的天花板效应，表明某些项目存在冗余。该经过精心设计的 PROM 的英国版本表现出良好的表面和结构有效性。然而，在这些量表中存在一定程度的冗余，进一步使用更大样本的 Rasch 分析将有助于解决这一问题。
