基因组分析揭示了瑞典斯德哥尔摩耐万古霉素屎肠球菌ST80的不同传播簇。
Genomic analysis revealed distinct transmission clusters of vancomycin-resistant Enterococcus faecium ST80 in Stockholm, Sweden.
作者信息
Fang H, Fröding I, Ullberg M, Giske C G
机构信息
Department of Clinical Microbiology, Karolinska University Hospital, Stockholm, Sweden; Division of Clinical Microbiology, Department of Laboratory Medicine, Karolinska Institutet, Stockholm, Sweden.
Department of Clinical Microbiology, Karolinska University Hospital, Stockholm, Sweden; Division of Clinical Microbiology, Department of Laboratory Medicine, Karolinska Institutet, Stockholm, Sweden.
出版信息
J Hosp Infect. 2021 Jan;107:12-15. doi: 10.1016/j.jhin.2020.10.019. Epub 2020 Oct 27.
Vancomycin-resistant Enterococcus faecium (VREfm) belonging to sequence type (ST)80 has become the predominant clonal lineage in Stockholm in the last three years. ST80 accounted for 75% and 46% of VRE cases in 2018 and 2019, respectively, and gave rise to both vanA-type and vanB-type outbreaks. Non-duplicate ST80-VREfm isolates (N = 188) were subjected to whole genome sequencing. Genomic analysis revealed three distinct transmission clusters. Our study indicated that difficulties in detecting low-grade vancomycin-resistant isolates by phenotypic testing might be one of the explanatory factors for the prolonged course of vanB-type outbreaks. Herein, we also report the first optrA-positive linezolid-resistant VRE isolate in Stockholm.
在过去三年中，属于序列型（ST）80的耐万古霉素屎肠球菌（VREfm）已成为斯德哥尔摩的主要克隆谱系。ST80分别占2018年和2019年VRE病例的75%和46%，并引发了vanA型和vanB型暴发。对188株非重复ST80-VREfm分离株进行了全基因组测序。基因组分析揭示了三个不同的传播簇。我们的研究表明，通过表型检测难以检测出低水平耐万古霉素分离株可能是vanB型暴发病程延长的解释因素之一。在此，我们还报告了斯德哥尔摩首例optrA阳性的耐利奈唑胺VRE分离株。
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