Ikeda S, Wong C W, Allsop D, Landon M, Kidd M, Glenner G G
Department of Pathology School of Medicine, University of California, San Diego, La Jolla.
Lab Invest. 1987 Oct;57(4):446-9.
A monoclonal antibody raised to a synthetic peptide consisting of residues 8 to 17 of the amyloid beta protein of Alzheimer's disease was employed for immunogold electron microscopic studies on amyloid fibrils of cerebrovascular walls and neuritic plaques in this disease. Electron microscopy revealed a specific gold labeling of the amyloid fibrils in these structures. This provides ultrastructural evidence that beta protein is intimately associated with the amyloid fibril. With previous chemical evidence, this observation supports the concentration that it is an intrinsic component of the fibril.
一种针对由阿尔茨海默病β淀粉样蛋白第8至17位残基组成的合成肽产生的单克隆抗体，用于对该疾病脑血管壁淀粉样纤维和神经炎性斑块进行免疫金电子显微镜研究。电子显微镜显示这些结构中的淀粉样纤维有特异性金标记。这提供了超微结构证据，表明β蛋白与淀粉样纤维密切相关。结合先前的化学证据，这一观察结果支持了β蛋白是纤维内在成分的观点。
