Shanghai Engineering Research Center of Food Microbiology, School of Medical Instrument and Food Engineering, University of Shanghai for Science and Technology, Shanghai, 200093, China.
Mol Biol Rep. 2020 Nov;47(11):9149-9157. doi: 10.1007/s11033-020-05930-5. Epub 2020 Oct 30.
Cyclic dimeric adenosine 3'-5'-monophosphate (c-di-AMP) is a recently discovered nucleotide messenger in bacteria. It plays an important role in signaling, transcription, and cell physiology, such as in bacterial growth, potassium transport, fatty acid synthesis, the metabolic balance of cell wall components, and biofilm formation. Exopolysaccharides (EPSs) have distinct physico-chemical properties and diverse bioactivities including antibacterial, hypolipidemic, and antioxidative activities, and they are widely used in the food, pharmaceutical, and cosmetic industries. Although c-di-AMP has been demonstrated to regulate the biosynthesis of bacterial EPSs, only a single c-di-AMP receptor, CabpA, has been identified in EPS synthesis. With the aim of describing current understanding of the regulation of microbial EPSs, this review summarizes c-di-AMP biosynthesis and degradation as well as the mechanism through which c-di-AMP regulates bacterial EPSs.
环状二核苷酸 3′-5′-环单磷酸（c-di-AMP）是最近在细菌中发现的一种核苷酸信使。它在信号转导、转录和细胞生理等方面发挥着重要作用，如细菌生长、钾转运、脂肪酸合成、细胞壁成分的代谢平衡和生物膜形成。胞外多糖（EPSs）具有独特的物理化学性质和多种生物活性，包括抗菌、降血脂和抗氧化活性，广泛应用于食品、制药和化妆品行业。尽管 c-di-AMP 已被证明可调节细菌 EPS 的生物合成，但在 EPS 合成中仅鉴定出单一的 c-di-AMP 受体 CabpA。本综述旨在描述目前对微生物 EPS 调控的理解，总结 c-di-AMP 的生物合成和降解以及 c-di-AMP 调节细菌 EPS 的机制。
