变形链球菌胞外多糖合成与生物膜形成的调控机制
Regulatory mechanisms of exopolysaccharide synthesis and biofilm formation in Streptococcus mutans.
作者信息
Zheng Ting, Jing Meiling, Gong Tao, Yan Jiangchuan, Wang Xiaowan, Xu Mai, Zhou Xuedong, Zeng Jumei, Li Yuqing
机构信息
State Key Laboratory of Oral Diseases, National Clinical Research Center for Oral Diseases, West China Hospital of Stomatology, Sichuan University, Chengdu, China.
Department of Operative Dentistry and Endodontics, West China Hospital of Stomatology, Sichuan University, Chengdu, China.
出版信息
J Oral Microbiol. 2023 Jun 18;15(1):2225257. doi: 10.1080/20002297.2023.2225257. eCollection 2023.
BACKGROUND
Dental caries is a chronic, multifactorial and biofilm-mediated oral bacterial infection affecting almost every age group and every geographical region. is considered an important pathogen responsible for the initiation and development of dental caries. It produces exopolysaccharides to promote the colonization of cariogenic bacteria and coordinate dental biofilm development.
OBJECTIVE
The understanding of the regulatory mechanism of biofilm formation can provide a theoretical basis for the prevention and treatment of caries.
DESIGN
At present, an increasing number of studies have identified many regulatory systems in that regulate biofilm formation, including second messengers (e.g. c-di-AMP, Ap4A), transcription factors (e.g. EpsR, RcrR, StsR, AhrC, FruR), two-component systems (e.g. CovR, VicR), small RNA (including sRNA0426, srn92532, and srn133489), acetylation modifications (e.g. ActG), CRISPR-associated proteins (e.g. Cas3), PTS systems (e.g. EIIAB), quorum-sensing signaling system (e.g. LuxS), enzymes (including Dex, YidC, CopZ, EzrA, lmrB, SprV, RecA, PdxR, MurI) and small-molecule metabolites.
RESULTS
This review summarizes the recent progress in the molecular regulatory mechanisms of exopolysaccharides synthesis and biofilm formation in .
背景
龋齿是一种慢性、多因素且由生物膜介导的口腔细菌感染，几乎影响每个年龄组和每个地理区域。被认为是导致龋齿发生和发展的重要病原体。它产生胞外多糖以促进致龋菌的定植并协调牙菌斑生物膜的形成。
目的
了解生物膜形成的调控机制可为龋齿的防治提供理论依据。
设计
目前，越来越多的研究已在中鉴定出许多调节生物膜形成的调控系统，包括第二信使（如环二腺苷酸、Ap4A）、转录因子（如EpsR、RcrR、StsR、AhrC、FruR）、双组分系统（如CovR、VicR）、小RNA（包括sRNA0426、srn92532和srn133489）、乙酰化修饰（如ActG）、CRISPR相关蛋白（如Cas3）、磷酸转移酶系统（如EIIAB）、群体感应信号系统（如LuxS）、酶（包括Dex、YidC、CopZ、EzrA、lmrB、SprV、RecA、PdxR、MurI）和小分子代谢物。
结果
本综述总结了在胞外多糖合成和生物膜形成的分子调控机制方面的最新进展。
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