Bartram C R, Böhlke J V, Adolph S, Hameister H, Ganser A, Anger B, Heisterkamp N, Groffen J
Department of Pediatrics II, University of Ulm, Federal Republic of Germany.
Leukemia. 1987 Feb;1(2):146-9.
Southern blot analyses demonstrated hemizygosity of c-fms sequences in three cases of the 5q- syndrome, cytogenetically characterized by del(5)(q13;q35) or del(5)(q31;q35). In situ hybridization studies revealed a deletion of this oncogene from the 5q- chromosome in two cases; moreover, we localized c-fms to region 5q31-33.
Southern印迹分析表明，在3例5q-综合征患者中，c-fms序列呈半合子状态，其细胞遗传学特征为del(5)(q13;q35)或del(5)(q31;q35)。原位杂交研究显示，2例患者的5q-染色体上该癌基因存在缺失；此外，我们将c-fms定位于5q31-33区域。
