Department of Dermatology, Hospital Universitario Fundación Jiménez Díaz, Universidad Autónoma, Madrid, Spain.
Department of Pathology, Hospital Universitario Fundación Jiménez Díaz, Universidad Autónoma, Madrid, Spain.
J Cutan Pathol. 2021 Jan;48(1):180-183. doi: 10.1111/cup.13908. Epub 2020 Nov 10.
Toker cells (TCs) are sometimes present in the nipple epidermis as oval cells with pale cytoplasm and roundish nuclei. In most cases, TCs may be easily distinguished from cancerous cells of Paget disease of the nipple (PCs). Especially in TC hyperplasia, in which mild-to-moderate atypia may be present, it may be challenging to distinguish between TCs and PCs. The combination of chronic inflammatory changes in the nipple, in the context of Zuska disease, and TC hyperplasia, may easily lead to an erroneous diagnosis of mammary Paget disease.
受器细胞（TCs）有时存在于乳头表皮中，呈椭圆形，胞浆淡染，核圆形。在大多数情况下，TCs 很容易与乳头派杰病（PCs）的癌细胞区分开来。特别是在 TCs 增生中，可能存在轻至中度异型性，区分 TCs 和 PCs 可能具有挑战性。在 Zuska 病的情况下，乳头的慢性炎症改变与 TCs 增生相结合，很容易导致对乳腺派杰病的错误诊断。
