van der Putte S C, Toonstra J, Hennipman A
Department of Pathology, University Hospital Utrecht, The Netherlands.
Am J Dermatopathol. 1995 Oct;17(5):487-93. doi: 10.1097/00000372-199510000-00010.
A hitherto unreported variant of mammary Paget's disease (MPD) limited to the areola, leaving the nipple unaffected, has been analyzed by serial sectioning of the whole areola and nipple. This otherwise characteristic MPD proved to be confined to the epidermis. There was no underlying carcinoma. This MPD was associated with a multifocal presence of monomorphic but otherwise similar cells in small collections surrounding the ostia of areolar mammary glands in the clinically unaffected area. This condition was interpreted as hyperplasia of mammary gland-related cells also found in normal nipples (so-called Toker cells). The observations hint at a possible derivation of some cases of mammary and extramammary Paget's disease from such Toker cells.
通过对整个乳晕和乳头进行连续切片，分析了一种迄今为止未报告的局限于乳晕、乳头未受影响的乳腺佩吉特病（MPD）变体。这种具有其他典型特征的MPD被证明局限于表皮。不存在潜在的癌。这种MPD与临床未受影响区域乳晕乳腺腺管开口周围小簇状分布的单形但其他方面相似的细胞的多灶性存在相关。这种情况被解释为在正常乳头中也发现的乳腺相关细胞的增生（所谓的托克尔细胞）。这些观察结果提示某些乳腺和乳腺外佩吉特病病例可能起源于此类托克尔细胞。
