Abarca J, Odilla Arrollo C, Blanch S, Arellano G
Servicio de Dermatología, Hospital J. J. Aguirre, Santiago, Chile.
Med Cutan Ibero Lat Am. 1987;15(3):199-203.
65 pregnant women distributed in two groups, by a double-blind method received a placebo or a sunscreen cream (Pabafil SPF 10, with absorption range from 290 to 360 nm) for daily use on face during the second quarter of their pregnancy in summer time. In 30 patients "with optimum fulfillment" in the products application (16 with placebo and 14 with sunscreen cream) the melasma appearances were significantly lower in those with sunscreen application. In subgroups of the total number of pregnant women, with similar proportion of patients with placebo and sunscreen, the melasma appearances were significantly lower in skin types I-II, and in those that used cosmetics (versus those that did not). No differences were observed in subgroups by age, parity, and with or without history of previous melasma.
65名孕妇被分为两组，采用双盲法，一组在夏季怀孕的第二季度每天面部使用安慰剂，另一组每天面部使用防晒霜（Pabafil SPF 10，吸收范围为290至360纳米）。在30名“产品使用情况良好”的患者中（16名使用安慰剂，14名使用防晒霜），使用防晒霜的患者黄褐斑出现率明显更低。在孕妇总数的亚组中，安慰剂组和防晒霜组患者比例相似，在I-II型皮肤以及使用化妆品的孕妇（与未使用化妆品的孕妇相比）中，黄褐斑出现率明显更低。在按年龄、产次以及有无黄褐斑病史划分的亚组中未观察到差异。
