Vázquez M, Sánchez J L
Cutis. 1983 Jul;32(1):92, 95-6.
A double-blind study comparing a broad-spectrum sunscreen agent with its vehicle in the treatment of melasma was performed in fifty-three patients who were concomitantly using a depigmentating solution. In this study, 96.2 percent of those who used the sunscreen agent showed improvement as compared with 80.7 percent of those who used placebo. These results confirm the positive role of sun protection in the treatment of melasma and also establish hydroquinone as a major therapeutic agent in pigmentary disorders.
一项双盲研究对53名同时使用脱色溶液的患者进行，比较了一种广谱防晒剂与其赋形剂在治疗黄褐斑方面的效果。在这项研究中，使用防晒剂的患者中有96.2%病情有所改善，而使用安慰剂的患者这一比例为80.7%。这些结果证实了防晒在黄褐斑治疗中的积极作用，同时也确立了对苯二酚作为色素沉着紊乱主要治疗药物的地位。
