Center for Observational and Real-World Evidence, Merck & Co., Inc., Kenilworth, NJ, USA.
Merck Animal Health, 2 Giralda Farms, Madison, NJ, USA.
Parasit Vectors. 2020 Oct 31;13(1):541. doi: 10.1186/s13071-020-04415-5.
Safe and effective flea and tick treatment options for cats are important in companion animal practice because of feline ectoparasite infestation prevalence and the potential for parasitic disease transmission. Retrospective cat owner purchasing transactions at United States of America (USA) veterinary clinics were obtained for three topical feline flea and tick ectoparasiticides. One medication, fluralaner, had a 12-week redosing interval, while two other medications (fipronil/s-methoprene/pyriproxyfen; imidacloprid/pyriproxyfen) were approved for monthly redosing. The annual number of doses purchased by cat owners was determined for each of the three medications and then compared between medications. The objective was to evaluate whether 12-week retreatment intervals resulted in a different duration of coverage compared to monthly treatments for ectoparasiticide products.
Study results were obtained by analyzing the transactional records from a commercial database derived from veterinary practice management software. The study database consisted of cat owner purchasing records from January 2017 through June 2019 from 671 veterinary practices representing 41,630 cats.
Cat owners purchased an average of 1.5 doses of fluralaner per year which, based on a 12-week redosing interval, provides 4.2 months of treatment coverage. Cat owners who used monthly flea and tick medications respectively purchased 3.6 months (fipronil/s-methoprene/pyriproxyfen combination) and 2.8 months (imidacloprid/pyriproxyfen) annually of each of the two medications. Average yearly cat owner purchases of fluralaner provide a significantly longer duration of coverage than for cat owners purchasing fipronil/s-methoprene/pyriproxyfen (17% more) or imidacloprid/pyriproxyfen (50% more).
Cat owners who obtained a flea and tick treatment with a 12-week redosing interval (fluralaner) protected their cats for up to 17% or 50% longer duration each year, respectively, compared to the duration of protection obtained by cat owners who used a medication re-dosed monthly. Cat owners should increase their duration of flea and tick coverage to come closer to achieving veterinary recommendations.
在伴侣动物实践中,安全有效的猫用跳蚤和蜱虫防治选择方案非常重要,因为猫科动物的体外寄生虫感染率很高,而且有寄生虫病传播的风险。从美国的兽医诊所获得了三种局部用猫用跳蚤和蜱虫驱虫药的回顾性猫主人购买交易数据。一种药物氟雷拉纳的给药间隔为 12 周,而另外两种药物(氟虫腈/甲氧普烯/吡丙醚;吡虫啉/吡丙醚)则被批准每月给药。根据三种药物中的每一种,确定了猫主人每年购买的剂量数,然后比较了药物之间的差异。目的是评估与每月治疗相比,12 周的重复治疗间隔是否会对驱虫产品的防治持续时间产生不同的影响。
通过分析来自商业数据库的交易记录,从兽医实践管理软件中获得研究结果。研究数据库由 2017 年 1 月至 2019 年 6 月期间,来自 671 家兽医诊所的 41630 只猫的猫主人购买记录组成。
猫主人平均每年购买 1.5 剂氟雷拉纳,根据 12 周的重复治疗间隔,提供了 4.2 个月的治疗覆盖。使用每月跳蚤和蜱虫药物的猫主人每年分别购买了 3.6 个月(氟虫腈/甲氧普烯/吡丙醚组合)和 2.8 个月(吡虫啉/吡丙醚)的两种药物。猫主人每年购买氟雷拉纳的平均剂量提供了明显更长的防治持续时间,比购买氟虫腈/甲氧普烯/吡丙醚(多 17%)或吡虫啉/吡丙醚(多 50%)的猫主人更长。
与使用每月重剂量的药物的猫主人相比,每年获得 12 周重复治疗间隔(氟雷拉纳)的猫主人的猫的保护时间分别延长了 17%或 50%,从而获得了更长的防治持续时间。猫主人应增加跳蚤和蜱虫的防治持续时间,以更接近兽医的建议。