Department of Biochemistry, Faculty of Sciences, University of Agriculture, Faisalabad 38000, Pakistan.
Department of Biochemistry, Faculty of Sciences, University of Agriculture, Faisalabad 38000, Pakistan.
Life Sci. 2021 Jan 1;264:118679. doi: 10.1016/j.lfs.2020.118679. Epub 2020 Oct 29.
Humanin (HN) is a small mitochondrial-derived cytoprotective polypeptide encoded by mtDNA. HN exhibits protective effects in several cell types, including leukocytes, germ cells, neurons, tissues against cellular stress conditions and apoptosis through regulating various signaling mechanisms, such as JAK/STAT pathway and interaction of BCL-2 family of protein. HN is an essential cytoprotective peptide in the human body that regulates mitochondrial functions under stress conditions. The present review aims to evaluate HN peptide's antiapoptotic activities as a potential therapeutic target in the treatment of cancer, diabetes mellitus, male infertility, bone-related diseases, cardiac diseases, and brain diseases. Based on in vitro and in vivo studies, HN significantly suppressed the apoptosis during the treatment of bone osteoporosis, cardiovascular diseases, diabetes mellitus, and neurodegenerative diseases. According to accumulated data, it is concluded that HN exerts the proapoptotic activity of TNF-α in cancer, which makes HN as a novel therapeutic agent in the treatment of cancer and suggested that along with HN, the development of another mitochondrial-derived peptide could be a viable therapeutic option against different oxidative stress and apoptosis-related diseases.
人源神经保护因子（HN）是一种由线粒体 DNA 编码的小型线粒体衍生的细胞保护多肽。HN 通过调节 JAK/STAT 途径和 BCL-2 家族蛋白的相互作用等多种信号机制，在包括白细胞、生殖细胞、神经元、组织在内的多种细胞类型中表现出对细胞应激和细胞凋亡的保护作用。HN 是人体内一种重要的细胞保护肽，可调节应激条件下的线粒体功能。本综述旨在评估 HN 肽作为治疗癌症、糖尿病、男性不育、骨相关疾病、心脏疾病和脑部疾病的潜在治疗靶点的抗细胞凋亡活性。基于体外和体内研究，HN 显著抑制了骨质疏松症、心血管疾病、糖尿病和神经退行性疾病治疗过程中的细胞凋亡。根据积累的数据，得出结论，HN 在癌症中发挥 TNF-α的促细胞凋亡作用，这使得 HN 成为癌症治疗的一种新型治疗药物，并表明除了 HN 之外，另一种线粒体衍生肽的开发可能是针对不同氧化应激和细胞凋亡相关疾病的可行治疗选择。
