Life Sciences Institute, Department of Medical Genetics, University of British Columbia, Vancouver, British Columbia, Canada; Department of Genetics, Medical University of Vienna, Vienna, Austria; Department of Immunology, University of Toronto, Toronto, Ontario, Canada.
Department of Ophthalmology and Visual Sciences, University of Alabama, Birmingham, Alabama.
Gastroenterology. 2021 Jan;160(1):39-46. doi: 10.1053/j.gastro.2020.07.067. Epub 2020 Oct 30.
The role of angiotensin converting enzyme 2 has expanded from regulating the renin angiotensin system to regulating intestinal amino acid homeostasis and the gut microbiome. Recently, angiotensin converting enzyme 2 was identified as a primary receptor for severe acute respiratory syndrome coronaviruses 1 and 2 being expressed in multiple tissues including the luminal surface of the gut. In this brief perspective, we examine the role of angiotensin converting enzyme 2 as the receptor for severe acute respiratory syndrome coronavirus 2 and the impact of coronavirus disease 19 infection on the gut microbiome and on the gut epithelium.
血管紧张素转换酶 2 的作用已经从调节肾素-血管紧张素系统扩展到调节肠道氨基酸稳态和肠道微生物组。最近，血管紧张素转换酶 2 被确定为严重急性呼吸综合征冠状病毒 1 和 2 的主要受体，在包括肠道腔表面在内的多种组织中表达。在这篇简短的观点文章中，我们研究了血管紧张素转换酶 2 作为严重急性呼吸综合征冠状病毒 2 受体的作用，以及冠状病毒病 19 感染对肠道微生物组和肠道上皮的影响。
