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血管紧张素转化酶 2 在调节肠道微生物群、肠道炎症和冠状病毒感染中的作用。

The Role of Angiotensin Converting Enzyme 2 in Modulating Gut Microbiota, Intestinal Inflammation, and Coronavirus Infection.

机构信息

Life Sciences Institute, Department of Medical Genetics, University of British Columbia, Vancouver, British Columbia, Canada; Department of Genetics, Medical University of Vienna, Vienna, Austria; Department of Immunology, University of Toronto, Toronto, Ontario, Canada.

Department of Ophthalmology and Visual Sciences, University of Alabama, Birmingham, Alabama.

出版信息

Gastroenterology. 2021 Jan;160(1):39-46. doi: 10.1053/j.gastro.2020.07.067. Epub 2020 Oct 30.

DOI:10.1053/j.gastro.2020.07.067
PMID:33130103
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC7836226/
Abstract

The role of angiotensin converting enzyme 2 has expanded from regulating the renin angiotensin system to regulating intestinal amino acid homeostasis and the gut microbiome. Recently, angiotensin converting enzyme 2 was identified as a primary receptor for severe acute respiratory syndrome coronaviruses 1 and 2 being expressed in multiple tissues including the luminal surface of the gut. In this brief perspective, we examine the role of angiotensin converting enzyme 2 as the receptor for severe acute respiratory syndrome coronavirus 2 and the impact of coronavirus disease 19 infection on the gut microbiome and on the gut epithelium.

摘要

血管紧张素转换酶 2 的作用已经从调节肾素-血管紧张素系统扩展到调节肠道氨基酸稳态和肠道微生物组。最近，血管紧张素转换酶 2 被确定为严重急性呼吸综合征冠状病毒 1 和 2 的主要受体，在包括肠道腔表面在内的多种组织中表达。在这篇简短的观点文章中，我们研究了血管紧张素转换酶 2 作为严重急性呼吸综合征冠状病毒 2 受体的作用，以及冠状病毒病 19 感染对肠道微生物组和肠道上皮的影响。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/8b2f/7836226/81a04164b5b7/gr2_lrg.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/8b2f/7836226/8821cb6602bb/gr1_lrg.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/8b2f/7836226/81a04164b5b7/gr2_lrg.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/8b2f/7836226/8821cb6602bb/gr1_lrg.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/8b2f/7836226/81a04164b5b7/gr2_lrg.jpg

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本文引用的文献

[1]
SARS-CoV-2 Infections and ACE2: Clinical Outcomes Linked With Increased Morbidity and Mortality in Individuals With Diabetes.

Diabetes. 2020-7-15

[2]
Alterations in Gut Microbiota of Patients With COVID-19 During Time of Hospitalization.

Gastroenterology. 2020-5-20

[3]
Associations Between Angiotensin-Converting Enzyme Inhibitors and Angiotensin II Receptor Blocker Use, Gastrointestinal Symptoms, and Mortality Among Patients With COVID-19.

Gastroenterology. 2020-9

[4]
Persistent viral shedding of SARS-CoV-2 in faeces - a rapid review.

Colorectal Dis. 2020-6-4

[5]
Age, Inflammation, and Disease Location Are Critical Determinants of Intestinal Expression of SARS-CoV-2 Receptor and in Inflammatory Bowel Disease.

Gastroenterology. 2020-9

[6]
Manifestations and prognosis of gastrointestinal and liver involvement in patients with COVID-19: a systematic review and meta-analysis.

Lancet Gastroenterol Hepatol. 2020-5-12

[7]
Infection of bat and human intestinal organoids by SARS-CoV-2.

Nat Med. 2020-5-13

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TMPRSS2 and TMPRSS4 promote SARS-CoV-2 infection of human small intestinal enterocytes.

Sci Immunol. 2020-5-13

[9]
Autopsy Findings and Venous Thromboembolism in Patients With COVID-19: A Prospective Cohort Study.

Ann Intern Med. 2020-5-6

[10]
SARS-CoV-2 productively infects human gut enterocytes.

Science. 2020-5-1

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