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Modeling mammalian hibernation to improve organ cold preservation: Using the intestine as an example.

作者信息

He Weiya, He Ziqing, Deng Wenjun, Wu Chuman, Huang Wenjie, Li Changhui, Liang Yan, Chen Yifu, Luo Renjie, Zhao Yifei, Liao Jiayu, Zhou Xin, Chen Guokai, Xu Ren-He, Liu Meiling, Dong Ji

机构信息

Faculty of Health Sciences and UM-Bioland Joint Laboratory, University of Macau, Macau, China.

Innovation Center for Evolutionary Synthetic Biology, School of Life Sciences, Sun Yat-sen University, Guangzhou, Guangdong, China.

出版信息

Cell Res. 2025 Jul 28. doi: 10.1038/s41422-025-01149-w.

DOI:10.1038/s41422-025-01149-w
PMID:40721538
Abstract
摘要

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本文引用的文献

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Comparison of the effects of normothermic machine perfusion and cold storage preservation on porcine intestinal allograft regenerative potential and viability.常温机械灌注与低温冷藏保存对猪肠同种异体移植物再生潜能和活力影响的比较。
Am J Transplant. 2024 Apr;24(4):564-576. doi: 10.1016/j.ajt.2023.10.026. Epub 2023 Oct 31.
2
Angiotensin-converting enzyme 2-at the heart of the COVID-19 pandemic.血管紧张素转化酶 2——新冠疫情的核心。
Cell. 2023 Mar 2;186(5):906-922. doi: 10.1016/j.cell.2023.01.039. Epub 2023 Feb 2.
3
Imatinib and methazolamide ameliorate COVID-19-induced metabolic complications via elevating ACE2 enzymatic activity and inhibiting viral entry.
伊马替尼和氨苯蝶啶通过提高 ACE2 酶活性和抑制病毒进入来改善 COVID-19 引起的代谢并发症。
Cell Metab. 2022 Mar 1;34(3):424-440.e7. doi: 10.1016/j.cmet.2022.01.008. Epub 2022 Feb 11.
4
From the freezer to the clinic: Antifreeze proteins in the preservation of cells, tissues, and organs.从冰箱到临床：抗冻蛋白在细胞、组织和器官保存中的应用。
EMBO Rep. 2021 Mar 3;22(3):e52162. doi: 10.15252/embr.202052162. Epub 2021 Feb 15.
5
The Role of Angiotensin Converting Enzyme 2 in Modulating Gut Microbiota, Intestinal Inflammation, and Coronavirus Infection.血管紧张素转化酶 2 在调节肠道微生物群、肠道炎症和冠状病毒感染中的作用。
Gastroenterology. 2021 Jan;160(1):39-46. doi: 10.1053/j.gastro.2020.07.067. Epub 2020 Oct 30.
6
ACE2 contributes to the maintenance of mouse epithelial barrier function.ACE2 有助于维持小鼠的上皮屏障功能。
Biochem Biophys Res Commun. 2020 Dec 17;533(4):1276-1282. doi: 10.1016/j.bbrc.2020.10.002. Epub 2020 Oct 21.
7
Cellular, Molecular, and Physiological Adaptations of Hibernation: The Solution to Environmental Challenges.冬眠的细胞、分子和生理适应性：应对环境挑战的解决方案。
Annu Rev Cell Dev Biol. 2020 Oct 6;36:315-338. doi: 10.1146/annurev-cellbio-012820-095945. Epub 2020 Sep 8.
8
ACE2 imbalance as a key player for the poor outcomes in COVID-19 patients with age-related comorbidities - Role of gut microbiota dysbiosis.ACE2 失衡是与年龄相关合并症的 COVID-19 患者预后不良的关键因素 - 肠道微生物失调的作用。
Ageing Res Rev. 2020 Sep;62:101123. doi: 10.1016/j.arr.2020.101123. Epub 2020 Jul 16.
9
Angiotensin-converting enzyme 2 (ACE2), SARS-CoV-2 and the pathophysiology of coronavirus disease 2019 (COVID-19).血管紧张素转化酶 2（ACE2）、严重急性呼吸综合征冠状病毒 2（SARS-CoV-2）与 2019 冠状病毒病（COVID-19）的病理生理学。
J Pathol. 2020 Jul;251(3):228-248. doi: 10.1002/path.5471. Epub 2020 Jun 10.
10
Mechanisms regulating intestinal barrier integrity and its pathological implications.调节肠道屏障完整性的机制及其病理意义。
Exp Mol Med. 2018 Aug 16;50(8):1-9. doi: 10.1038/s12276-018-0126-x.