Swann P F, Graves R J, Mace R
Institute of Biochemistry, Middlesex Hospital, Medical School, London, Great Britain.
Mutat Res. 1987 Nov;186(3):261-7. doi: 10.1016/0165-1110(87)90008-x.
Alcohol consumption is associated with an increase in the incidence of cancers of several sites, including oesophagus, larynx and mouth. The mechanism of the induction of cancer by alcohol is not clear. Humans are exposed to a variety of carcinogenic N-nitroso compounds. Ethanol changes the pharmacokinetics of nitrosamines in rats particularly by decreasing the ability of the liver to metabolize them. A hypothesis is put forward that the influence of alcohol on human cancer is mediated by its effect on the metabolism and distribution of nitrosamines from the diet, from tobacco smoke and from endogenous synthesis.
饮酒与包括食管癌、喉癌和口腔癌在内的多个部位癌症发病率的增加有关。酒精诱发癌症的机制尚不清楚。人类会接触到多种致癌的N-亚硝基化合物。乙醇改变了大鼠体内亚硝胺的药代动力学，特别是通过降低肝脏代谢它们的能力。有人提出一种假说，即酒精对人类癌症的影响是通过其对饮食、烟草烟雾和内源性合成中亚硝胺的代谢和分布的作用来介导的。
