胃印戒细胞癌和黏液腺癌的预后分析：倾向评分匹配研究和竞争风险分析。

Prognostic analysis of gastric signet ring cell carcinoma and mucinous carcinoma: a propensity score-matched study and competing risk analysis.

机构信息

Department of Gastroenterology, The First Affiliated Hospital of Nanchang University, Nanchang, China.

出版信息

Aging (Albany NY). 2020 Nov 20;12(21):22059-22077. doi: 10.18632/aging.104048.

BACKGROUND

Limited evidence and contradictory results have been reported regarding the impact of signet ring cell carcinoma (SRC) and mucinous gastric cancer (MGC) classifications on the prognosis of gastric cancer (GC).

RESULTS

Information on 6017 patients and 266 patients was extracted from the SEER database and our hospital records, respectively. We found that patients with MGC had a better survival rate than those with SRC (P=0.012), but in the early stage, MGC was a risk factor for a poor prognosis. After PSM, for both patients from the SEER database and our hospital, the prognosis of patients with SRC was poorer than that of patients with MGC (P<0.05), but patients with MGC in early-stage GC showed poorer survival. Additionally, SRC was demonstrated to be a risk factor in the multivariate competing risk regression model for cancer-specific survival.

CONCLUSION

Patients with SRC may have a worse prognosis than those with MGC, but for early-stage GC, patients with SRC have a better prognosis than those with MGC.

METHOD

Patients from the SEER database and from our hospital diagnosed with SRC or MGC were included in a Cox regression analysis, multivariate competing risk model and propensity score matching (PSM) analysis.

背景

关于印戒细胞癌（SRC）和黏液腺癌（MGC）分类对胃癌（GC）预后的影响，已有有限的证据和相互矛盾的结果报道。

结果

从 SEER 数据库和我院病历中分别提取了 6017 例和 266 例患者的信息。我们发现 MGC 患者的生存率优于 SRC 患者（P=0.012），但在早期，MGC 是预后不良的危险因素。PSM 后，无论是来自 SEER 数据库还是我院的患者，SRC 患者的预后均比 MGC 患者差（P<0.05），但早期 GC 患者的 MGC 生存率较差。此外，SRC 在用于癌症特异性生存的多变量竞争风险回归模型中被证明是一个危险因素。