Department of Food Science and Human Nutrition, Setsunan University.
Department of Cardiology, National Hospital Organization Tokyo Medical Center.
J Atheroscler Thromb. 2021 Nov 1;28(11):1195-1203. doi: 10.5551/jat.59899. Epub 2020 Oct 30.
Kinin B1 receptor (KB1R) was shown to be up-regulated in human carotid atherosclerotic lesions. Serum KB1R levels were also reported to be high in patients with stroke. However, KB1R deficiency increased atherosclerotic lesions. Therefore, the role of KB1R in atherosclerosis remains unclear. Moreover, no study has reported blood KB1R levels in patients with coronary artery disease (CAD).
We measured plasma KB1R levels in 375 patients undergoing coronary angiography. The severity of CAD was represented as the numbers of ＞50% stenotic vessels and segments and the severity score.
CAD was found in 197 patients, of whom 89 had 1-vessel disease (1-VD), 62 had 2-VD, and 46 had 3-VD. Plasma KB1R levels were higher in 197 patients with CAD than in 178 without CAD (median 83.3 vs. 73.7 pg/mL, p＜0.01). A stepwise increase in KB1R levels was found depending on the number of stenotic vessels: 77.1 in 1-VD, 87.8 in 2-VD, and 88.5 pg/mL in 3-VD (p＜0.025). A high KB1R level (＞90.0 pg/mL) was present in 30% of patients with CAD(-), 39% of 1-VD, 50% of 2-VD, and 48% of 3-VD (p＜0.025). KB1R levels correlated with the number of stenotic segments and the severity score (r=0.14 and r=0.17, p＜0.01). In multivariate analysis, KB1R levels were an independent factor associated with CAD. Odds ratio for CAD was 1.62 (95%CI=1.02-2.58) for high KB1R level ＞90.0 pg/mL.
Plasma KB1R levels in patients with CAD were high and were associated with the presence and severity of CAD independent of atherosclerotic risk factors.
已有研究表明，激肽 B1 受体（KB1R）在人颈动脉粥样硬化病变中上调。据报道，中风患者的血清 KB1R 水平也较高。然而，KB1R 缺乏会增加动脉粥样硬化病变。因此，KB1R 在动脉粥样硬化中的作用尚不清楚。此外，尚无研究报告过冠心病（CAD）患者的血液 KB1R 水平。
我们测量了 375 名接受冠状动脉造影的患者的血浆 KB1R 水平。CAD 的严重程度表示为＞50%狭窄血管和节段的数量和严重程度评分。
197 名患者发现有 CAD，其中 89 名有 1 支血管病变（1-VD），62 名有 2 支血管病变，46 名有 3 支血管病变。与 178 名无 CAD 的患者相比，CAD 患者的血浆 KB1R 水平更高（中位数为 83.3 vs. 73.7 pg/mL，p＜0.01）。根据狭窄血管数量发现 KB1R 水平呈逐步升高：1-VD 为 77.1 pg/mL，2-VD 为 87.8 pg/mL，3-VD 为 88.5 pg/mL（p＜0.025）。30%的 CAD（-）患者、39%的 1-VD 患者、50%的 2-VD 患者和 48%的 3-VD 患者存在高 KB1R 水平（＞90.0 pg/mL）（p＜0.025）。KB1R 水平与狭窄节段数量和严重程度评分相关（r=0.14 和 r=0.17，p＜0.01）。在多变量分析中，KB1R 水平是 CAD 的独立相关因素。高 KB1R 水平（＞90.0 pg/mL）的 CAD 比值比为 1.62（95%CI=1.02-2.58）。
CAD 患者的血浆 KB1R 水平较高，与 CAD 的存在和严重程度相关，独立于动脉粥样硬化危险因素。
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