• 文献检索
  • 文档翻译
  • 深度研究
  • 学术资讯
  • Suppr Zotero 插件Zotero 插件
  • 邀请有礼
  • 套餐&价格
  • 历史记录
应用&插件
Suppr Zotero 插件Zotero 插件浏览器插件Mac 客户端Windows 客户端微信小程序
定价
高级版会员购买积分包购买API积分包
服务
文献检索文档翻译深度研究API 文档MCP 服务
关于我们
关于 Suppr公司介绍联系我们用户协议隐私条款
关注我们

Suppr 超能文献

核心技术专利：CN118964589B侵权必究
粤ICP备2023148730 号-1Suppr @ 2026

文献检索

告别复杂PubMed语法，用中文像聊天一样搜索，搜遍4000万医学文献。AI智能推荐，让科研检索更轻松。

立即免费搜索

文件翻译

保留排版，准确专业，支持PDF/Word/PPT等文件格式，支持 12+语言互译。

免费翻译文档

深度研究

AI帮你快速写综述，25分钟生成高质量综述，智能提取关键信息，辅助科研写作。

立即免费体验

PTPN11 mutations are associated with poor outcomes across myeloid malignancies.

作者信息

Swoboda David M, Ali Najla Al, Chan Onyee, Padron Eric, Kuykendall Andrew T, Song Jinming, Hussaini Mohammad, Talati Chetasi, Sweet Kendra, Lancet Jeffrey E, Sallman David A, Komrokji Rami S

机构信息

Department of Hematology and Oncology, H. Lee Moffitt Cancer Center, Tampa, FL, USA.

Department of Malignant Hematology, H. Lee Moffitt Cancer Center, Tampa, FL, USA.

出版信息

Leukemia. 2021 Jan;35(1):286-288. doi: 10.1038/s41375-020-01083-3. Epub 2020 Nov 1.

DOI:10.1038/s41375-020-01083-3
PMID:33132383
Abstract
摘要

相似文献

1
PTPN11 mutations are associated with poor outcomes across myeloid malignancies.PTPN11突变与所有髓系恶性肿瘤的不良预后相关。
Leukemia. 2021 Jan;35(1):286-288. doi: 10.1038/s41375-020-01083-3. Epub 2020 Nov 1.
2
Childhood Myeloid Neoplasms With PTPN11 Mutations in Brazil.巴西伴有PTPN11突变的儿童髓系肿瘤
Clin Lymphoma Myeloma Leuk. 2020 Aug;20(8):e496-e505. doi: 10.1016/j.clml.2020.04.009. Epub 2020 Apr 20.
3
Activating mutations in protein tyrosine phosphatase Ptpn11 (Shp2) enhance reactive oxygen species production that contributes to myeloproliferative disorder.蛋白酪氨酸磷酸酶 Ptpn11（Shp2）中的激活突变增强了活性氧的产生，这有助于骨髓增生性疾病的发生。
PLoS One. 2013 May 10;8(5):e63152. doi: 10.1371/journal.pone.0063152. Print 2013.
4
Co-occurrence of hypertrophic cardiomyopathy and myeloproliferative disorder in a neonate with Noonan syndrome carrying Thr73Ile mutation in PTPN11.一名患有努南综合征且PTPN11基因存在Thr73Ile突变的新生儿同时患有肥厚型心肌病和骨髓增殖性疾病。
Am J Med Genet A. 2015 Dec;167A(12):3144-7. doi: 10.1002/ajmg.a.37295. Epub 2015 Aug 19.
5
Characterization of acute myeloid leukemia with PTPN11 mutation: the mutation is closely associated with NPM1 mutation but inversely related to FLT3/ITD.伴有PTPN11突变的急性髓系白血病的特征：该突变与NPM1突变密切相关，但与FLT3/ITD呈负相关。
Leukemia. 2008 May;22(5):1075-8. doi: 10.1038/sj.leu.2405005. Epub 2007 Nov 1.
6
Myelodysplastic syndrome with multilineage dysplasia evolving to acute myeloid leukemia: Noonan syndrome with c.218C>T mutation in PTPN11 gene.伴有多系发育异常并进展为急性髓系白血病的骨髓增生异常综合征：PTPN11基因存在c.218C>T突变的努南综合征。
Pediatr Blood Cancer. 2019 Feb;66(2):e27527. doi: 10.1002/pbc.27527. Epub 2018 Oct 30.
7
Hemophagocytosis associated with leukemia: a striking association with juvenile myelomonocytic leukemia.噬血细胞综合征与白血病相关：与幼年型粒单核细胞白血病的显著关联。
Ann Hematol. 2010 Apr;89(4):359-64. doi: 10.1007/s00277-009-0837-0. Epub 2009 Oct 2.
8
Acute myeloid leukemia with inversion 16 and a novel PTPN11 mutation: A case report with literature review.伴有16号染色体倒位及新型PTPN11突变的急性髓系白血病：一例报告并文献复习
Int J Lab Hematol. 2024 Feb;46(1):195-198. doi: 10.1111/ijlh.14191. Epub 2023 Oct 24.
9
Activating mutations of the noonan syndrome-associated SHP2/PTPN11 gene in human solid tumors and adult acute myelogenous leukemia.人类实体瘤和成人急性髓性白血病中与努南综合征相关的SHP2/PTPN11基因的激活突变。
Cancer Res. 2004 Dec 15;64(24):8816-20. doi: 10.1158/0008-5472.CAN-04-1923.
10
Somatic mutations in PTPN11 in juvenile myelomonocytic leukemia, myelodysplastic syndromes and acute myeloid leukemia.青少年粒单核细胞白血病、骨髓增生异常综合征和急性髓系白血病中PTPN11的体细胞突变。
Nat Genet. 2003 Jun;34(2):148-50. doi: 10.1038/ng1156.

引用本文的文献

1
Next-generation sequencing reveals relapse and leukemia-free survival risks in newly diagnosed acute myeloid leukemia treated with CAG regimen combined with decitabine.下一代测序揭示了接受CAG方案联合地西他滨治疗的新诊断急性髓系白血病的复发风险和无白血病生存风险。
Cancer Pathog Ther. 2023 Oct 12;2(2):112-120. doi: 10.1016/j.cpt.2023.10.002. eCollection 2024 Apr.
2
Analysis of the clinical characteristics and prognosis of adult acute myeloid leukemia (none APL) with mutations.成人急性髓系白血病（非急性早幼粒细胞白血病）伴突变的临床特征及预后分析
Open Med (Wars). 2023 Nov 3;18(1):20230830. doi: 10.1515/med-2023-0830. eCollection 2023.
3
Clinical Characteristics and Prognosis of Acute Myeloid Leukemia Patients with Protein Tyrosine Phosphatase Non-Receptor Type 11 Gene Mutation.
具有蛋白酪氨酸磷酸酶非受体11型基因突变的急性髓系白血病患者的临床特征与预后
Pharmgenomics Pers Med. 2023 Nov 11;16:1011-1026. doi: 10.2147/PGPM.S420254. eCollection 2023.
4
The clinical features and prognostic implications of PTPN11 mutation in adult patients with acute myeloid leukemia in China.中国成人急性髓系白血病患者 PTPN11 突变的临床特征和预后意义。
Cancer Med. 2023 Dec;12(23):21111-21117. doi: 10.1002/cam4.6669. Epub 2023 Nov 8.
5
Targeting integrated stress response with ISRIB combined with imatinib treatment attenuates RAS/RAF/MAPK and STAT5 signaling and eradicates chronic myeloid leukemia cells.靶向整合应激反应的 ISRIB 联合伊马替尼治疗可抑制 RAS/RAF/MAPK 和 STAT5 信号通路并根除慢性髓性白血病细胞。
BMC Cancer. 2022 Dec 2;22(1):1254. doi: 10.1186/s12885-022-10289-w.
6
CSF3R T618I mutant myelodysplastic/myeloproliferative neoplasm in the elderly: An age-related disease with unfavorable prognosis.老年CSF3R T618I突变型骨髓增生异常/骨髓增殖性肿瘤：一种预后不良的年龄相关性疾病。
Leuk Res Rep. 2022 Jun 25;17:100334. doi: 10.1016/j.lrr.2022.100334. eCollection 2022.
7
Molecular, clinical, and prognostic implications of PTPN11 mutations in acute myeloid leukemia.PTPN11 突变在急性髓系白血病中的分子、临床和预后意义。
Blood Adv. 2022 Mar 8;6(5):1371-1380. doi: 10.1182/bloodadvances.2021006242.
8
Impact of PTPN11 mutations on clinical outcome analyzed in 1529 patients with acute myeloid leukemia.在 1529 例急性髓系白血病患者中分析 PTPN11 突变对临床结局的影响。
Blood Adv. 2021 Sep 14;5(17):3279-3289. doi: 10.1182/bloodadvances.2021004631.