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一种类似于胆囊收缩素羧基末端八肽的肽在兔脑中的免疫组织化学定位。

Immunohistochemical localization in rabbit brain of a peptide resembling the COOH-terminal octapeptide of cholecystokinin.

作者信息

Straus E, Muller J E, Choi H S, Paronetto F, Yalow R S

出版信息

Proc Natl Acad Sci U S A. 1977 Jul;74(7):3033-4. doi: 10.1073/pnas.74.7.3033.

DOI:10.1073/pnas.74.7.3033
PMID:331325
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC431396/
Abstract

Immunohistochemical techniques were used to demonstrate the presence of a material resembling the COOH-terminal octapeptide of cholecystokinin in rabbit cerebral cortical neurons. Deep staining was seen in cell bodies throughout the cortical grey matter and diffusely in the subcortical white matter.

摘要

采用免疫组织化学技术来证明在兔大脑皮质神经元中存在一种类似于胆囊收缩素羧基末端八肽的物质。在整个皮质灰质的细胞体中可见深染色，在皮质下白质中呈弥漫性染色。

相似文献

1
Immunohistochemical localization in rabbit brain of a peptide resembling the COOH-terminal octapeptide of cholecystokinin.一种类似于胆囊收缩素羧基末端八肽的肽在兔脑中的免疫组织化学定位。
Proc Natl Acad Sci U S A. 1977 Jul;74(7):3033-4. doi: 10.1073/pnas.74.7.3033.
2
Cholecystokinin and its COOH-terminal octapeptide in the pig brain.猪脑中的胆囊收缩素及其羧基末端八肽。
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3
Substance P and cholecystokinin-like peptides in Helix neurons and cholecystokinin and serotonin in a giant neuron.在蜗牛神经元中的P物质和胆囊收缩素样肽以及在一个巨型神经元中的胆囊收缩素和5-羟色胺。
Science. 1982 Apr 23;216(4544):409-11. doi: 10.1126/science.6176023.
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Localization of cholecystokinin-octapeptide-like-immunoreactivity in neurons cultured from rat cerebral cortex.大鼠大脑皮层培养神经元中胆囊收缩素八肽样免疫反应性的定位
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Demonstration of biological activity of brain gastrin-like peptidic material in the human: its relationship with the COOH-terminal octapeptide of cholecystokinin.人脑胃泌素样肽类物质生物活性的证明：其与胆囊收缩素羧基末端八肽的关系。
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In vivo synthesis of cholecystokinin in the rat cerebral cortex: identification of COOH-terminal peptides with labeled amino acids.
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Localization of cholecystokinin-like immunoreactivity in isolated nerve terminals.胆囊收缩素样免疫反应性在分离神经末梢中的定位。
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Immunoreactive component resembling cholecystokinin octapeptide in intestine.
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Immunohistochemical localization of cholecystokinin- and gastrin-like peptides in the brain and hypophysis of the rat.
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Neuropeptide-containing neurons of the cerebral cortex are also GABAergic.大脑皮层中含神经肽的神经元也是γ-氨基丁酸能的。
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引用本文的文献

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Ultrastructural identification of Gastrin-like immunoreactive nerve fibres in the brain of Xenopus laevis by means of colloidal gold or ferritin immunocytochemical methods.运用胶体金或铁蛋白免疫细胞化学方法对非洲爪蟾脑内胃泌素样免疫反应性神经纤维进行超微结构鉴定。
Cell Tissue Res. 1981;216(3):581-9. doi: 10.1007/BF00238653.
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Localization by immunofluorescence of a gastrin-like substance in the brain of the rainbow trout, Salmo gairdneri.用免疫荧光法对虹鳟鱼（Salmo gairdneri）大脑中一种胃泌素样物质进行定位。
Cell Tissue Res. 1981;214(2):247-55. doi: 10.1007/BF00249209.
3
Immunohistochemical localization of cholecystokinin- and gastrin-like peptides in the brain and hypophysis of the rat.

本文引用的文献

1
An unidentified depressor substance in certain tissue extracts.某些组织提取物中一种不明的降压物质。
J Physiol. 1931 Jun 6;72(1):74-87. doi: 10.1113/jphysiol.1931.sp002763.
2
The hypothalamus in pituitary-thyroid regulation.垂体-甲状腺调节中的下丘脑。
Recent Prog Horm Res. 1972;28:229-86.
3
The unlabeled antibody enzyme method of immunohistochemistry: preparation and properties of soluble antigen-antibody complex (horseradish peroxidase-antihorseradish peroxidase) and its use in identification of spirochetes.免疫组织化学的未标记抗体酶法：可溶性抗原-抗体复合物（辣根过氧化物酶-抗辣根过氧化物酶）的制备、性质及其在螺旋体鉴定中的应用
Proc Natl Acad Sci U S A. 1980 Feb;77(2):1190-4. doi: 10.1073/pnas.77.2.1190.
4
Transport of cholecystokinin-octapeptide-like immunoreactivity toward the gut in afferent vagal fibres in cat and dog.猫和犬传入迷走神经纤维中胆囊收缩素八肽样免疫反应性物质向肠道的运输。
J Physiol. 1981 May;314:501-11. doi: 10.1113/jphysiol.1981.sp013721.
5
Influence of cholecystokinin octapeptide sulfate ester on brain monoamine metabolism in rats.硫酸缩胆囊素八肽对大鼠脑单胺代谢的影响。
J Neural Transm. 1981;50(2-4):81-8. doi: 10.1007/BF01249131.
6
Neuropeptides and monoaminergic neurotransmitters: their relation to pain.神经肽与单胺能神经递质：它们与疼痛的关系。
J R Soc Med. 1980 Jul;73(7):482-91. doi: 10.1177/014107688007300704.
7
Ontogeny of cholecystokinin-8 and glutamic acid decarboxylase in cerebral neocortex of macaque monkey.猕猴大脑新皮质中胆囊收缩素-8和谷氨酸脱羧酶的个体发生
Exp Brain Res. 1989;74(2):249-55. doi: 10.1007/BF00248857.
8
Brain cholecystokinin and nutritional status in rats and mice.大鼠和小鼠的脑胆囊收缩素与营养状况
J Clin Invest. 1979 Nov;64(5):1348-56. doi: 10.1172/JCI109591.
9
Species specificity of cholecystokinin in gut and brain of several mammalian species.几种哺乳动物肠道和大脑中胆囊收缩素的物种特异性
Proc Natl Acad Sci U S A. 1978 Jan;75(1):486-9. doi: 10.1073/pnas.75.1.486.
10
Immunohistochemical localization of a gastrin-like peptide in the brain of an amphibian, Xenopus laevis Daud.一种胃泌素样肽在两栖动物非洲爪蟾（Xenopus laevis Daud.）脑内的免疫组织化学定位
Cell Tissue Res. 1979 Nov;203(1):65-78. doi: 10.1007/BF00234329.
J Histochem Cytochem. 1970 May;18(5):315-33. doi: 10.1177/18.5.315.
4
The effects of substance P and other peptides on spinal neurons of the frog.P物质及其他肽类对青蛙脊髓神经元的影响。
Brain Res. 1974 Jan 18;65(3):397-410. doi: 10.1016/0006-8993(74)90231-5.
5
Cholecystokinin and its COOH-terminal octapeptide in the pig brain.猪脑中的胆囊收缩素及其羧基末端八肽。
Proc Natl Acad Sci U S A. 1977 Jul;74(7):3035-7. doi: 10.1073/pnas.74.7.3035.
6
Peptides and neuronal function.肽与神经元功能。
Adv Biochem Psychopharmacol. 1976;15:193-210.