D'Haese Pierre-François, Ranjan Manish, Song Alexander, Haut Marc W, Carpenter Jeffrey, Dieb Gerard, Najib Umer, Wang Peng, Mehta Rashi I, Chazen J Levi, Hodder Sally, Claassen Daniel, Kaplitt Michael, Rezai Ali R
Rockefeller Neuroscience Institute, West Virginia University, Morgantown, WV, United States.
Department of Electrical Engineering and Computer Science, Vanderbilt University, Nashville, TN, United States.
Front Hum Neurosci. 2020 Oct 7;14:593672. doi: 10.3389/fnhum.2020.593672. eCollection 2020.
The blood-brain barrier (BBB) limits therapeutic delivery in Alzheimer's disease (AD) and other neurological disorders. Animal models have demonstrated safe BBB opening and reduction in β-amyloid plaque with focused ultrasound (FUS). We recently demonstrated the feasibility, safety, and reversibility of FUS-induced BBB opening in the hippocampus and entorhinal cortex in six participants with early AD. We now report the effect of BBB opening with FUS treatment on β-amyloid plaque. Six participants underwent F-Florbetaben PET scan at baseline and 1 week after the completion of the third FUS treatment (60 days interval). PET analysis comparing the hippocampus and entorhinal cortex in the treated and untreated hemispheres revealed a decrease in the ratio of F-Florbetaben ligand binding. The standard uptake value ratios (SUVr) reduction ranged from 2.7% to 10% with an average of 5.05% (±2.76) suggesting a decrease in β-amyloid plaque.
血脑屏障（BBB）限制了阿尔茨海默病（AD）及其他神经疾病的治疗药物递送。动物模型已证明，聚焦超声（FUS）可安全打开血脑屏障并减少β-淀粉样蛋白斑块。我们最近证实了FUS诱导早期AD的6名参与者海马体和内嗅皮质血脑屏障开放的可行性、安全性和可逆性。我们现在报告FUS治疗引起的血脑屏障开放对β-淀粉样蛋白斑块的影响。6名参与者在基线时以及第三次FUS治疗完成后1周（间隔60天）接受了F-氟代贝他班PET扫描。PET分析比较了治疗侧和未治疗侧半球的海马体和内嗅皮质，结果显示F-氟代贝他班配体结合率降低。标准摄取值比率（SUVr）下降范围为2.7%至10%，平均为5.05%（±2.76），表明β-淀粉样蛋白斑块减少。
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