Institute of Reproductive Health, Center for Reproductive Medicine, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China.
Am J Reprod Immunol. 2021 Nov;86(5):e13487. doi: 10.1111/aji.13487. Epub 2021 Aug 9.
A successful pregnancy is a complex and unique process comprised of discrete events, including embryo implantation, placentation, and parturition. To maintain the balance between maternal-fetal immune tolerance and resistance to infections, the maternal immune system must have a high degree of stage-dependent plasticity throughout the period of pregnancy. Innate immunity is the frontline force for the establishment of early anti-infection and tolerance mechanisms in mammals. Belonging to the innate immune system, a subset of T cells called γδT cells (based on γδT cell receptors) are the main participants in immune surveillance and immune defense. Unlike traditional αβT cells, γδT cells are regarded as a bridge between innate immunity and acquired immunity. In this review, we summarize current knowledge on the functional plasticity of γδT cells during pregnancy. Furthermore, we discuss the roles of γδT cells in pathological pregnancies.
成功的妊娠是一个复杂而独特的过程，由多个离散事件组成，包括胚胎着床、胎盘形成和分娩。为了在妊娠期间维持母体-胎儿免疫耐受和抗感染能力之间的平衡，母体免疫系统必须在整个孕期具有高度的阶段依赖性可塑性。先天免疫是哺乳动物早期抗感染和耐受机制建立的第一道防线。属于先天免疫系统的一类 T 细胞，即 γδT 细胞（基于 γδT 细胞受体），是免疫监视和免疫防御的主要参与者。与传统的 αβT 细胞不同，γδT 细胞被认为是先天免疫和获得性免疫之间的桥梁。在这篇综述中，我们总结了 γδT 细胞在妊娠期间功能可塑性的最新知识。此外，我们还讨论了 γδT 细胞在病理性妊娠中的作用。
