Liu Dong, Lin Ge, Su Dejun, Alexender James M, Sun Xiaoting, Qu Ming
University of Nebraska Medical Center, College of Public Health, 984355 Medical Center, Omaha, NE 68198-4355, United States.
Nebraska Department of Health and Human Services, 301 Centennial Mall South, Lincoln, NE 68509, United States.
Prev Med Rep. 2020 Oct 19;20:101226. doi: 10.1016/j.pmedr.2020.101226. eCollection 2020 Dec.
Nebraska births between 1995 and 2005 were followed until 2018 to look for intergenerational associations of low birth weight (LBW) and preterm birth (PTB). Results from generalized estimating equations revealed that mothers born LBW preterm were more likely to deliver LBW (adjusted OR 1.94, 95% CI 1.39-2.71) or preterm (adjusted OR 1.65, 95% CI 1.20-2.27) than mothers born with normal weight or at term. In addition, mothers who had an LBW sibling were 44% more likely to have an LBW infant (OR 1.44, 95% CI 1.04-2.00). A consistent finding was also observed for mothers who had a PTB sibling (OR 1.47, 95% CI 1.10-1.95). Mothers who were LBW at birth or had any LBW siblings, especially two or more siblings, were more likely to repeat this adverse birth outcome. The same association was also observed in mothers who were born preterm.
对1995年至2005年在 Nebraska 出生的婴儿进行随访直至2018年，以寻找低出生体重（LBW）和早产（PTB）的代际关联。广义估计方程的结果显示，出生时低体重或早产的母亲比出生时体重正常或足月的母亲更有可能分娩出低体重儿（校正比值比1.94，95%置信区间1.39 - 2.71）或早产（校正比值比1.65，95%置信区间1.20 - 2.27）。此外，有低体重同胞的母亲生出低体重婴儿的可能性要高44%（比值比1.44，95%置信区间1.04 - 2.00）。对于有早产同胞的母亲也观察到了一致的结果（比值比1.47，95%置信区间1.10 - 1.95）。出生时低体重或有任何低体重同胞的母亲，尤其是有两个或更多同胞的母亲，更有可能再次出现这种不良出生结局。在早产的母亲中也观察到了同样的关联。
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