Friedman M I, Ramirez I
Monell Chemical Senses Center, Philadelphia, PA 19104.
Physiol Behav. 1987;40(5):655-9. doi: 10.1016/0031-9384(87)90113-2.
The effects of insulin administration of the reduction on food intake which follows a meal of corn oil was examined in normal and streptozotocin-diabetic rats. In the first experiment, a single injection of long-acting, protamine zinc insulin (3 IU) curtailed the decrease in 24-hr food intake that occurred in normal and diabetic rats after ingestion of 2.0 ml of oil. In a second experiment, injection of short-acting, regular insulin (0.5 IU) prevented the depression of food intake which occurred 6-24 hr after ingestion of 1.5 ml of corn oil, but not at earlier time intervals. In a third experiment, the short-term suppression of food intake in diabetic rats that occurred within 6 hr after a 1.5 ml meal of oil was reduced by chronic administration of insulin (3 IU/day) via a subcutaneously implanted osmotic pump. The results indicate that a relatively long-lasting effect of insulin counteracts the satiation from ingested fat and suggest that insulin's role in the control of food intake may depend on the composition of the diet.
在正常大鼠和链脲佐菌素诱导的糖尿病大鼠中，研究了注射胰岛素对玉米油餐后食物摄入量减少的影响。在第一个实验中，单次注射长效鱼精蛋白锌胰岛素（3国际单位）可减少正常大鼠和糖尿病大鼠在摄入2.0毫升油后24小时食物摄入量的下降。在第二个实验中，注射短效普通胰岛素（0.5国际单位）可防止在摄入1.5毫升玉米油后6 - 24小时出现的食物摄入量减少，但在更早的时间间隔内无效。在第三个实验中，通过皮下植入渗透泵慢性注射胰岛素（3国际单位/天）可减少糖尿病大鼠在摄入1.5毫升油餐后6小时内出现的短期食物摄入量抑制。结果表明，胰岛素的相对持久作用可抵消摄入脂肪产生的饱腹感，并提示胰岛素在控制食物摄入量方面的作用可能取决于饮食的组成。
