Willing A E, Walls E K, Koopmans H S
Department of Medical Science, University of Calgary, Alberta, Canada.
Physiol Behav. 1994 Nov;56(5):983-91. doi: 10.1016/0031-9384(94)90333-6.
The effects of insulin dose and diet composition on daily food intake were investigated by IV infusion of insulin in doses of 2 to 5 U/day into diabetic rats consuming either a high CHO or high fat diet. The daily food intake of the diabetic rats on both diets increased significantly over baseline levels (p < .01) at the low insulin doses and was maintained at these elevated levels through the 5 U/day dose. Insulin increased the rate of weight gain from Ig/day during baseline to 2 and 2.5 g/day in high CHO and high fat fed diabetics (p < .01). These results show that treatment of diabetic rats with continuous low doses of IV insulin results in a 40% increase in daily food intake regardless of the diet consumed and this increase is accompanied by an increase in rate of body weight gain. While the high fat fed diabetics were relatively hypoglycemic, these increases in intake are not the result of insulin-induced hypoglycemia, since blood glucose concentrations are significantly elevated when the increases occur at the lower insulin doses (p < .01). Thus, peripheralinsulin infused at physiological levels stimulates rather than inhibits daily food intake.
通过以每天2至5单位的剂量向食用高碳水化合物（CHO）或高脂肪饮食的糖尿病大鼠静脉输注胰岛素，研究了胰岛素剂量和饮食组成对每日食物摄入量的影响。两种饮食的糖尿病大鼠的每日食物摄入量在低胰岛素剂量时均比基线水平显著增加（p <.01），并在每天5单位的剂量下维持在这些升高的水平。胰岛素使高碳水化合物喂养和高脂肪喂养的糖尿病大鼠的体重增加速率从基线时的每天1克增加到每天2克和2.5克（p <.01）。这些结果表明，用连续低剂量的静脉胰岛素治疗糖尿病大鼠，无论食用何种饮食，每日食物摄入量都会增加40%，并且这种增加伴随着体重增加速率的提高。虽然高脂肪喂养的糖尿病大鼠相对低血糖，但摄入量的这些增加并非胰岛素诱导的低血糖所致，因为在较低胰岛素剂量下出现摄入量增加时，血糖浓度显著升高（p <.01）。因此，以生理水平输注的外周胰岛素刺激而非抑制每日食物摄入量。
