Surti Suleman, Pantel Austin R, Karp Joel S
Department of Radiology, University of Pennsylvania, Philadelphia, PA 19104, USA.
Departments of Radiology and Physics & Astronomy, University of Pennsylvania, Philadelphia, PA 19104, USA.
IEEE Trans Radiat Plasma Med Sci. 2020 May;4(3):283-292. doi: 10.1109/trpms.2020.2985403. Epub 2020 Apr 3.
PET instruments are now available with a long axial field-of-view (LAFOV) to enable imaging the total-body, or at least head and torso, simultaneously and without bed translation. This has two major benefits, a dramatic increase in system sensitivity and the ability to measure kinetics with wider axial coverage so as to include multiple organs. This manuscript presents a review of the technology leading up to the introduction of these new instruments, and explains the benefits of a LAFOV PET-CT instrument. To date there are two platforms developed for TB-PET, an outcome of the EXPLORER Consortium of the University of California at Davis (UC Davis) and the University of Pennsylvania (Penn). The uEXPLORER at UC Davis has an AFOV of 194 cm and was developed by United Imaging Healthcare. The PennPET EXPLORER was developed at Penn and is based on the digital detector from Philips Healthcare. This multi-ring system is scalable and has been tested with 3 rings but is now being expanded to 6 rings for 140 cm. Initial human studies with both EXPLORER systems have demonstrated the successful implementation and benefits of LAFOV scanners for both clinical and research applications. Examples of such studies are described in this manuscript.
现在有具备长轴向视野（LAFOV）的正电子发射断层扫描（PET）仪器，能够在不进行床位平移的情况下同时对全身，或至少对头部和躯干进行成像。这有两个主要优点，一是系统灵敏度显著提高，二是能够在更宽的轴向覆盖范围内测量动力学，从而涵盖多个器官。本文对这些新仪器推出之前的技术进行了综述，并解释了LAFOV PET-CT仪器的优点。迄今为止，为全身PET（TB-PET）开发了两个平台，这是加利福尼亚大学戴维斯分校（UC Davis）和宾夕法尼亚大学（Penn）的探索者联盟的成果。UC Davis的uEXPLORER轴向视野为194厘米，由联影医疗开发。宾夕法尼亚大学的探索者PET（PennPET EXPLORER）是在宾夕法尼亚大学开发的，基于飞利浦医疗的数字探测器。这个多环系统是可扩展的，已经用3个环进行了测试，但现在正在扩展到6个环，轴向视野为140厘米。对这两种探索者系统进行的初步人体研究已经证明了LAFOV扫描仪在临床和研究应用中的成功实施及其优点。本文描述了此类研究的实例。
