Shekarriz-Foumani Reza, Yassaee Fakhrolmolouk, Tarokh Sara, Taheri Mahbobeh
Department of Community Medicine, School of Medicine, Shahid Beheshti University of Medical Sciences, Tehran, Iran.
Department of Obstetrics and Gynecology, Genomic Research Center, Taleghani Hospital, Shahid Beheshti University of Medical Sciences, Tehran, Iran.
Int J Reprod Biomed. 2020 Oct 13;18(10):899-904. doi: 10.18502/ijrm.v13i10.7774. eCollection 2020 Oct.
There is evidence suggesting that the pregnancy outcome may be affected by some medical conditions, such as liver diseases.
The present study aimed to investigate the prevalence of liver disease and its outcomes in pregnant women referred to antenatal clinic in the hospital.
In this cross-sectional study, all pregnant women with abnormal liver function test attending antenatal clinic affiliated to Shahid Beheshti University of Medical Sciences were recruited from August 2017 to July 2018. All participants were followed-up until delivery with respect to the maternal and neonatal outcome.
Of a total of 7,121 pregnant women recruited in the study, 110 (1.58%) women were detected with a liver disease; of these, 105 women were diagnosed with pregnancy-specific liver diseases, including HELLP syndrome (10.9%), preeclampsia (50.98%), partial HELLP (0.9%), eclampsia (0.9%), acute fatty liver (9.1%), intra-hepatic cholestasis 25 (22.7%), and 5 women the non-pregnancy-specific liver disease, including Liver transplantation (2.7%), and Autoimmune hepatitis (1.8%). Prevalence of the premature birth was 64.5% in pregnancy-specific liver disease, but no premature birth was detected in cases with liver transplantation. We found that neonatal mortality was significantly associated with neonatal prematurity (p = 0.013), IUGR (p 0.001), placental pathology (p = 0.04), we had no maternal mortality.
Liver disease is not uncommon in pregnancy. This study demonstrated that pregnancy is safe in women with liver disease.
有证据表明，妊娠结局可能会受到一些疾病的影响，如肝脏疾病。
本研究旨在调查转诊至该医院产前门诊的孕妇中肝脏疾病的患病率及其结局。
在这项横断面研究中，2017年8月至2018年7月招募了所有在谢赫·贝赫什提医科大学附属产前门诊就诊且肝功能检查异常的孕妇。所有参与者均随访至分娩，观察母婴结局。
在本研究招募的7121名孕妇中，有110名（1.58%）被检测出患有肝脏疾病；其中，105名孕妇被诊断为妊娠特异性肝脏疾病，包括HELLP综合征（10.9%）、子痫前期（50.98%）、部分性HELLP（0.9%）、子痫（0.9%）、急性脂肪肝（9.1%）、肝内胆汁淤积症（22.7%），5名孕妇患有非妊娠特异性肝脏疾病，包括肝移植（2.7%）和自身免疫性肝炎（1.8%）。妊娠特异性肝脏疾病的早产患病率为64.5%，但肝移植病例中未检测到早产。我们发现新生儿死亡率与新生儿早产（p = （此处原文有误，推测应为p = 0.013））、胎儿生长受限（p 0.001）、胎盘病理（p = 0.04）显著相关，未出现孕产妇死亡。
肝脏疾病在孕期并不少见。本研究表明，患有肝脏疾病的女性妊娠是安全的。
