可见光诱导无金属条件下咪唑稠合杂环的磷酸化反应。
Visible-Light-Induced Phosphorylation of Imidazo-Fused Heterocycles under Metal-Free Conditions.
机构信息
Green Catalysis Center, College of Chemistry, Zhengzhou University, Kexue Road No. 100, Zhengzhou 450001, China.
Institute Drug Discovery Technology, Ningbo University, Ningbo 315211, Zhejiang, China.
出版信息
J Org Chem. 2020 Nov 20;85(22):14744-14752. doi: 10.1021/acs.joc.0c02107. Epub 2020 Nov 2.
PMID:33136392
Abstract
A metal-free and base-free procedure for the phosphorylation of imidazo[1,2-]pyridines with phosphine oxides under the irradiation of visible light at room temperature in green solvent was reported, featuring mild and sustainable conditions, convenient operation, as well as good functional group compatibility.
摘要
本文报道了一种在可见光照射下，于室温、绿色溶剂中，无需金属和碱，通过氧化膦对咪唑并[1,2-]吡啶进行磷酸化的方法。该方法具有条件温和、可持续、操作方便以及官能团兼容性好等优点。
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