接触镜传感器监测的眼压昼夜变化与青光眼视野缺损有关。
Nocturnal Variability of Intraocular Pressure Monitored With Contact Lens Sensor Is Associated With Visual Field Loss in Glaucoma.
机构信息
Viterbi Family Department of Ophthalmology and the Shiley Eye Institute, Hamilton Glaucoma Center, University of California, San Diego, La Jolla, CA.
Glaucoma Research Center, Montchoisi Clinic, Swiss Visio, Lausanne, Switzerland.
出版信息
J Glaucoma. 2021 Mar 1;30(3):e56-e60. doi: 10.1097/IJG.0000000000001727.
PURPOSE
The aim was to determine whether 24-hour recording of intraocular pressure (IOP)-related ocular dimensional changes with a contact lens sensor (CLS, Triggerfish) is associated with the rate of visual field (VF) progression in primary open-angle glaucoma (POAG) patients.
DESIGN
This was a retrospective, observational cohort study.
PARTICIPANTS
Patients with POAG were included from the Glaucoma Clinic and Diagnostic Innovations in Glaucoma Study at the Hamilton Glaucoma Center at University of California, San Diego.
METHODS
A session of 24-hour CLS recording was acquired for 1 eye from each patient. The mean follow-up time was 9.9±4.0 years. The association between CLS variables and rate of change of mean deviation was determined by univariate and multivariate mixed linear regression models.
RESULTS
Thirty-two patients, aged 69.8±13.6 years were included, 50% were female. An average of 11.6±5.6 standard automated perimetry examinations was available with a mean rate of mean deviation progression of -0.2±0.4 dB/year. Mean IOP was 17.8±4.2 mm Hg. The mean number of IOP-lowering medications were 1.2±1.0. Each 10-unit larger nocturnal variability of IOP-related ocular dimensional changes measured by CLS recording was significantly associated with -0.25±0.11 dB faster VF loss in POAG patients (P=0.035).
CONCLUSIONS
Twenty-four-hour CLS recording of IOP-related ocular dimensional change was associated with faster VF progression. Such CLS recordings are useful to assess the risk of in progression in POAG patients.
目的
旨在确定使用接触镜传感器（CLS，Triggerfish）记录 24 小时眼压（IOP）相关眼尺寸变化是否与原发性开角型青光眼（POAG）患者的视野（VF）进展速度有关。
设计
这是一项回顾性、观察性队列研究。
参与者
从加利福尼亚大学圣地亚哥分校 Hamilton 青光眼中心的青光眼诊所和青光眼诊断创新研究中招募了 POAG 患者。
方法
从每位患者的 1 只眼中采集了 24 小时 CLS 记录的一个时段。平均随访时间为 9.9±4.0 年。通过单变量和多变量混合线性回归模型确定 CLS 变量与平均偏差变化率之间的关联。
结果
纳入了 32 名年龄 69.8±13.6 岁的患者，其中 50%为女性。平均可获得 11.6±5.6 次标准自动视野检查，平均平均偏差进展率为-0.2±0.4 dB/年。平均 IOP 为 17.8±4.2 mmHg。平均使用 1.2±1.0 种降眼压药物。通过 CLS 记录测量的 IOP 相关眼尺寸变化的夜间变异性每增加 10 个单位，POAG 患者的 VF 损失速度就会加快 0.25±0.11 dB（P=0.035）。
结论
CLS 记录的 24 小时 IOP 相关眼尺寸变化与较快的 VF 进展有关。这种 CLS 记录对于评估 POAG 患者进展的风险很有用。
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