Opt Lett. 2020 Nov 1;45(21):5901-5904. doi: 10.1364/OL.403135.
The highest three-dimensional (3D) resolution possible in in vivo retinal imaging is achieved by combining optical coherence tomography (OCT) and adaptive optics. However, this combination brings important limitations, such as small field-of-view and complex, cumbersome systems, preventing so far the translation of this technology from the research lab to clinics. In this Letter, we mitigate these limitations by combining our compact time-domain full-field OCT (FFOCT) with a multi-actuator adaptive lens positioned just in front of the eye, in a technique we call the adaptive-glasses wavefront sensorless approach. Through this approach, we demonstrate that ocular aberrations can be corrected, increasing the FFOCT signal-to-noise ratio (SNR) and enabling imaging of different retinal layers with a 3D cellular resolution over a 5×5 field-of-view, without apparent anisoplanatism.
在体内视网膜成象中，所能达到的最高三维（3D）分辨率是通过将光学相干断层扫描（OCT）和自适应光学相结合来实现的。然而，这种组合带来了重要的限制，如视场小和复杂、繁琐的系统，迄今为止，这项技术还无法从研究实验室转化到临床。在这封信中，我们通过将我们的紧凑时域全场 OCT（FFOCT）与一个多执行器自适应透镜结合起来，在眼睛前面的位置，在我们称之为自适应眼镜无波前传感器的方法中，减轻了这些限制。通过这种方法，我们证明了可以矫正眼像差，提高 FFOCT 的信噪比（SNR），并在 5×5 的视场范围内实现不同视网膜层的成像，具有 3D 细胞分辨率，而没有明显的各向异性。
