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使用金字塔波前传感器的自适应光学光学相干断层扫描技术在视网膜前部成像中的速度、稳定性和视野的改进。

Improvements on speed, stability and field of view in adaptive optics OCT for anterior retinal imaging using a pyramid wavefront sensor.

作者信息

Brunner Elisabeth, Kunze Laura, Laidlaw Victoria, Jodlbauer Daniel, Drexler Wolfgang, Ramlau Ronny, Pollreisz Andreas, Pircher Michael

机构信息

Center for Medical Physics and Biomedical Engineering, Medical University of Vienna, Waehringer Guertel 18-20, A-1090 Wien, Austria.

Department of Ophthalmology and Optometry, Medical University of Vienna, Waehringer Guertel 18-20, A-1090 Wien, Austria.

出版信息

Biomed Opt Express. 2024 Sep 30;15(10):6098-6116. doi: 10.1364/BOE.533451. eCollection 2024 Oct 1.

DOI:10.1364/BOE.533451
PMID:39421790
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC11482182/
Abstract

We present improvements on the adaptive optics (AO) correction method using a pyramid wavefront sensor (P-WFS) and introduce a novel approach for closed-loop focus shifting in retinal imaging. The method's efficacy is validated through adaptive optics optical coherence tomography (AO-OCT) imaging in both, healthy individuals and patients with diabetic retinopathy. In both study groups, a stable focusing on the anterior retinal layers is achieved. We further report on an improvement in AO loop speed that can be used to expand the imaging area of AO-OCT in the slow scanning direction, largely independent of the eye's isoplanatic patch. Our representative AO-OCT data reveal microstructural details of the neurosensory retina such as vessel walls and microglia cells that are visualized in single volume data and over an extended field of view. The excellent performance of the P-WFS based AO-OCT imaging in patients suggests good clinical applicability of this technology.

摘要

我们展示了使用金字塔波前传感器（P-WFS）的自适应光学（AO）校正方法的改进，并介绍了一种用于视网膜成像中闭环焦点转移的新方法。该方法的有效性通过在健康个体和糖尿病视网膜病变患者中进行的自适应光学光学相干断层扫描（AO-OCT）成像得到验证。在两个研究组中，均实现了对视网膜前层的稳定聚焦。我们还报告了AO环速的提高，这可用于在慢扫描方向上扩大AO-OCT的成像区域，很大程度上与眼睛的等晕区无关。我们具有代表性的AO-OCT数据揭示了神经感觉视网膜的微观结构细节，如血管壁和小胶质细胞，这些在单体积数据和扩展视野中都能可视化。基于P-WFS的AO-OCT成像在患者中的出色表现表明该技术具有良好的临床适用性。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/4f43/11482182/67501d6ba225/boe-15-10-6098-g010.jpg
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