近年来，低频 Raman 光谱技术在药物应用方面取得了进展。

Recent advances in low-frequency Raman spectroscopy for pharmaceutical applications.

机构信息

The Dodd-Walls Centre for Photonic and Quantum Technologies, Department of Chemistry, University of Otago, Dunedin 9016, New Zealand.

出版信息

Int J Pharm. 2021 Jan 5;592:120034. doi: 10.1016/j.ijpharm.2020.120034. Epub 2020 Nov 1.

DOI:10.1016/j.ijpharm.2020.120034

PMID:33137450

Abstract

Low-frequency Raman (LFR) spectroscopy probes vibrational modes related to long-range order (i.e., crystallinity) that can provide unique information on the solid-state/structural characteristics among other properties. Furthermore, the recent advancements in instrumentation (most notably, narrow wavelength band filters) and data analysis has allowed to overcome some of the previous limitations of this technique. In fact, LFR spectroscopy has now enjoyed a surge in popularity with applications found in many research areas. This mini-review article provides a comprehensive summary of established and exciting new LFR applications for pharmaceutical analysis. Aspects of the underlying theory, instrumentation and data analysis (including application of chemometric and computational techniques) are also discussed in detail.

摘要

低频 Raman（LFR）光谱探测与长程有序（即结晶度）相关的振动模式，可提供有关固态/结构特性以及其他性质的独特信息。此外，仪器（尤其是窄波长带滤波器）和数据分析方面的最新进展，克服了该技术以前的一些局限性。实际上，LFR 光谱学现在在许多研究领域的应用中越来越受欢迎。本文综述了用于药物分析的成熟和令人兴奋的新 LFR 应用。本文还详细讨论了该技术的基本理论、仪器和数据分析（包括化学计量学和计算技术的应用）。