Department of Nutrition, School of Public Health, Iran University of Medical Sciences, Tehran, Iran.
Breast Disease Research Center(BDRC), Tehran University Of Medical Sciences, Tehran, Iran; Department of Obstetrics and Gynecology, Endocrinology and Female Infertility Unit, Arash Women's Hospital, Tehran University of Medical Sciences, Tehran, Iran; Department of Endocrinology and Female Infertility, Reproductive Biomedicine Research Center, Royan Institute for Reproductive Biomedicine, ACECR, Tehran, Iran.
Phytomedicine. 2021 Jan;80:153395. doi: 10.1016/j.phymed.2020.153395. Epub 2020 Oct 22.
Curcumin is a biologically active phytochemical ingredient found in turmeric. It has several pharmacologic effects that might benefit patients with polycystic ovary syndrome (PCOS).
We hypothesized curcumin to be effective in improving blood sugar levels, insulin resistance and hyperandrogenism in individuals with PCOS.
In a randomized double-blind placebo-controlled trial, individuals with PCOS were treated with curcumin (500 mg three times daily) or placebo for 12 weeks. Primary outcome measures were fasting plasma glucose (FPG), fasting insulin (FI), sex hormone levels, and hirsutism (Ferriman-Gallwey [mFG] score). Secondary outcomes included anthropometric measurements.
Of 72 randomized individuals, 67 completed the trial. The two groups were comparable at baseline. At the end of the study, FPG and Dehydroepiandrosterone levels had decreased significantly in the intervention group compared to control (difference of change (post-pre) between intervention and placebo groups: -4.11 mg/dL; 95% CI: -8.35, -0.35 mg/dL; p = 0.033 and -26.53 microg/dL; 95% CI: -47.99, -4.34 µg/dL; p = 0.035, respectively). We also observed a statistically non-significant increase (p = 0.082) in Estradiol levels in the intervention group compared to control. No serious adverse events were reported throughout the trial.
Curcumin might be a safe and useful supplement to ameliorate PCOS-associated hyperandrogenemia and hyperglycemia. However, longer trials investigating different dosages in longer durations are needed to underpin these findings.
姜黄素是一种存在于姜黄中的生物活性植物化学物质。它具有多种药理作用，可能有益于多囊卵巢综合征（PCOS）患者。
我们假设姜黄素能有效改善 PCOS 患者的血糖水平、胰岛素抵抗和高雄激素血症。
在一项随机、双盲、安慰剂对照试验中，PCOS 患者接受姜黄素（500mg，每日 3 次）或安慰剂治疗 12 周。主要结局指标为空腹血糖（FPG）、空腹胰岛素（FI）、性激素水平和多毛症（Ferriman-Gallwey[mFG]评分）。次要结局包括人体测量学指标。
在 72 名随机患者中，有 67 名完成了试验。两组在基线时具有可比性。研究结束时，与对照组相比，干预组的 FPG 和脱氢表雄酮水平显著降低（干预组与安慰剂组之间变化的差值（治疗前后）：-4.11mg/dL；95%可信区间：-8.35，-0.35mg/dL；p=0.033 和-26.53mcg/dL；95%可信区间：-47.99，-4.34mcg/dL；p=0.035）。我们还观察到干预组雌二醇水平有统计学上的非显著升高（p=0.082）。整个试验过程中均未报告严重不良事件。
姜黄素可能是一种安全有效的补充剂，可改善 PCOS 相关的高雄激素血症和高血糖症。然而，需要进行更长时间、不同剂量的试验来证实这些发现。
