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姜黄素及其制剂在多囊卵巢综合征治疗中的应用：当前见解与未来展望

Curcumin and its formulations for the treatment of polycystic ovary syndrome: current insights and future prospects.

作者信息

Mallya Pooja, Lewis Shaila A

机构信息

Department of Pharmaceutics, Manipal College of Pharmaceutical Sciences, Manipal Academy of Higher Education (MAHE), Manipal, Karnataka, 576104, India.

出版信息

J Ovarian Res. 2025 Apr 15;18(1):78. doi: 10.1186/s13048-025-01660-z.

DOI:10.1186/s13048-025-01660-z
PMID:40234918
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC12001734/
Abstract

Polycystic ovary syndrome (PCOS) is a common gynaecological complication with alarmingly high incidence of 6-20% in women of reproductive age and leads to multifaceted symptoms such as menstrual irregularities, hyperandrogenism, polycystic ovaries, and insulin resistance. Several therapeutic methods have been recommended for PCOS including lifestyle modification, insulin sensitizer (metformin), ovulation inducers (letrozole, clomiphene citrate), hormonal pills, and surgical intervention (ovarian drilling and oophorectomy); however, these treatment modalities often cause adverse effects. Currently, phytochemicals and plant extracts have been recommended for PCOS. Among these, few phytochemicals and their formulations, curcumin (CUR) (a bioactive polyphenol from Curcuma longa), has emerged as a promising complementary PCOS therapy due to its antioxidant, anti-inflammatory, insulin-sensitizing, and ovulation inducing properties. However, CUR's clinical application is hindered by poor solubility and bioavailability. In this review, we summarize and discuss various formulations of CUR and combination therapies that have demonstrated potential in treating PCOS in animal models.

摘要

多囊卵巢综合征（PCOS）是一种常见的妇科并发症，在育龄女性中的发病率高达6%-20%，令人担忧，它会导致月经不调、高雄激素血症、多囊卵巢和胰岛素抵抗等多方面症状。针对PCOS推荐了几种治疗方法，包括生活方式改变、胰岛素增敏剂（二甲双胍）、促排卵药物（来曲唑、枸橼酸氯米芬）、激素类药物以及手术干预（卵巢打孔术和卵巢切除术）；然而，这些治疗方式常常会引起不良反应。目前，植物化学物质和植物提取物已被推荐用于治疗PCOS。其中，少数植物化学物质及其制剂，如姜黄素（CUR）（一种来自姜黄的生物活性多酚），因其抗氧化、抗炎、胰岛素增敏和促排卵特性，已成为一种有前景的PCOS辅助治疗方法。然而，CUR的临床应用受到其低溶解度和低生物利用度的阻碍。在本综述中，我们总结并讨论了CUR的各种制剂以及在动物模型中已显示出治疗PCOS潜力的联合疗法。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/4036/12001734/0055475fad6d/13048_2025_1660_Fig9_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/4036/12001734/695b4c885af1/13048_2025_1660_Fig1_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/4036/12001734/3dc54e3ee3d9/13048_2025_1660_Fig2_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/4036/12001734/c5f2c6d98e0b/13048_2025_1660_Fig3_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/4036/12001734/2a5fd771fa4e/13048_2025_1660_Fig4_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/4036/12001734/bd5f800292ee/13048_2025_1660_Fig5_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/4036/12001734/92c7919024d7/13048_2025_1660_Fig6_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/4036/12001734/d3170cc3d3ad/13048_2025_1660_Fig7_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/4036/12001734/44304ff7681d/13048_2025_1660_Fig8_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/4036/12001734/0055475fad6d/13048_2025_1660_Fig9_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/4036/12001734/695b4c885af1/13048_2025_1660_Fig1_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/4036/12001734/3dc54e3ee3d9/13048_2025_1660_Fig2_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/4036/12001734/c5f2c6d98e0b/13048_2025_1660_Fig3_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/4036/12001734/2a5fd771fa4e/13048_2025_1660_Fig4_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/4036/12001734/bd5f800292ee/13048_2025_1660_Fig5_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/4036/12001734/92c7919024d7/13048_2025_1660_Fig6_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/4036/12001734/d3170cc3d3ad/13048_2025_1660_Fig7_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/4036/12001734/44304ff7681d/13048_2025_1660_Fig8_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/4036/12001734/0055475fad6d/13048_2025_1660_Fig9_HTML.jpg

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Curcumin and its formulations for the treatment of polycystic ovary syndrome: current insights and future prospects.

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引用本文的文献

[1]
Adipo-Modulation by Turmeric Bioactive Phenolic Components: From Curcuma Plant to Effects.

Int J Mol Sci. 2025-7-17

[2]
Recognizing the Role of Insulin Resistance in Polycystic Ovary Syndrome: A Paradigm Shift from a Glucose-Centric Approach to an Insulin-Centric Model.

J Clin Med. 2025-6-6

本文引用的文献

[1]
Curcumin and Metformin Infinite Coordination Polymer Nanoparticles for Combined Therapy of Diabetic Mice via Intraperitoneal Injections.

J Funct Biomater. 2024-12-21

[2]
Curcumin mitigates polycystic ovary syndrome in mice by suppressing TLR4/MyD88/NF-κB signaling pathway activation and reducing intestinal mucosal permeability.

Sci Rep. 2024-12-2

[3]
Effects of metformin and curcumin in women with polycystic ovary syndrome: A factorial clinical trial.

Phytomedicine. 2024-12

[4]
Two by Two Factorial Design using Metformin and Curcumin for Second Primary Head and Neck Cancer Prevention Trial.

Asian Pac J Cancer Prev. 2024-6-1

[5]
Therapeutic potential of acarbose in ameliorating the metabolic and endocrinological complications of polycystic ovarian syndrome: a review.

Curr Med Res Opin. 2024-7

[6]
Polysaccharide-fecal microbiota-based colon-targeted self-nanoemulsifying drug delivery system of curcumin for treating polycystic ovarian syndrome.

Naunyn Schmiedebergs Arch Pharmacol. 2024-9

[7]
Effect of nanocurcumin on fertility in murine model of polycystic ovary syndrome.

Vet Res Forum. 2024

[8]
Diagnosis and management of polycystic ovarian syndrome.

CMAJ. 2024-1-28

[9]
Role of Metformin in Polycystic Ovary Syndrome (PCOS)-Related Infertility.

Cureus. 2023-8-31

[10]
Metformin and curcumin co-encapsulated chitosan/alginate nanoparticles as effective oral carriers against pain-like behaviors in mice.

Int J Pharm. 2023-6-10

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