Freund U, Schölmerich J, Siems H, Kluge F, Schäfer H E, Wannenmacher M
Abteilung Röntgen- und Strahlentherapie, Universitätsklinik Freiburg.
Strahlenther Onkol. 1987 Oct;163(10):678-80.
In a prospective randomized placebo controlled double blind study, the prophylactic effect of mesalazine (5-aminosalicylic acid. 5-ASA) as suppositories (3 x 250 mg/day) on radiation induced proctitis during radiotherapy for prostatic carcinoma was studied. The study ended when 16 patients had been included (5-ASA: eight, placebo: eight) because of severe side effects in the 5-ASA group. 75% of patients treated with 5-ASA reported symptoms of a severe proctitis while only one patient in the placebo group had similar complaints. The application of mesalazine as suppositories is not useful in preventing radiation induced proctitis during radiotherapy of prostate carcinoma.
在一项前瞻性随机安慰剂对照双盲研究中，研究了美沙拉嗪（5-氨基水杨酸，5-ASA）栓剂（3×250毫克/天）对前列腺癌放疗期间放射性直肠炎的预防作用。由于5-ASA组出现严重副作用，在纳入16名患者（5-ASA组：8名，安慰剂组：8名）后研究结束。接受5-ASA治疗的患者中有75%报告有严重直肠炎症状，而安慰剂组只有1名患者有类似主诉。美沙拉嗪栓剂在预防前列腺癌放疗期间的放射性直肠炎方面并无用处。
