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症状性子宫破裂:十五年回顾

Symptomatic Uterine Rupture: A Fifteen Year Review.

作者信息

Savukyne Egle, Bykovaite-Stankeviciene Raimonda, Machtejeviene Egle, Nadisauskiene Ruta, Maciuleviciene Regina

机构信息

Department of Obstetrics and Gynaecology, Medical Academy, Lithuanian University of Health Sciences, Kaunas LT-50161, Lithuania.

出版信息

Medicina (Kaunas). 2020 Oct 29;56(11):574. doi: 10.3390/medicina56110574.

Abstract

To assess the incidence of complete and partial uterine rupture during childbirth in a single tertiary referral centre as well as the significant risk factors, symptoms and peripartum complications. A retrospective single-centre study involved all cases of uterine rupture at the Kaunas Perinatal Centre in 2004-2019. Data were from a local medical database complemented with written information from medical records. We included 45,893 women with an intact uterus and 5630 with uterine scars. Women ( = 5626) with scarred uterus' after previous cesarean delivery. The diagnosis was defined by clinical symptoms, leading to an emergency cesarean delivery, when complete or partial uterine rupture ( = 35) was confirmed. Asymptomatic cases, when uterine rupture was found at elective cesarean section ( = 3), were excluded. The control group is represented by all births delivered in our department during the study period ( = 51,525). The outcome was complete (tearing of all uterine wall layers, including serosa and membranes) and partial uterine rupture (uterine muscle defect but intact serosa), common uterine rupture symptoms. Risk factors were parameters related to pregnancy and labour. 51,525 deliveries occurred in Kaunas Perinatal Centre during the 15 years of the study period. A total number of 35 (0.06%) symptomatic uterine ruptures were recorded: 22 complete and 13 partial, leading to an incidence rate of 6.8 per 10,000 deliveries. The uterine rupture incidence rate after a single previous cesarean delivery is 44.4 per 10,000 births. 29 (83%) cases had a uterine scar after previous cesarean, 4 (11%) had a previous laparoscopic myomectomy, 2 (6%) had an unscarred uterus. The most significant risk factors of uterine rupture include uterine scarring and augmentation or epidural anaesthesia in patients with a uterine scar after cesarean delivery. The most common clinical sign was acute abdominal pain in labour 18 (51%). No maternal, six intrapartum perinatal deaths (17%) occurred, and one hysterectomy (2.8%) was performed due to uterine rupture. Neonatal mortality reached 22% among the complete ruptures. Average blood loss was 1415 mL, 4 (11%) patients required blood transfusion. The incidence rate of uterine rupture (complete and incomplete) at Kaunas Perinatal Centre is 6.8 per 10,000 deliveries. In cases with a scar of the uterus after a single cesarean, the incidence of uterine rupture is higher, exceeding 44 cases per 10,000 births. The most significant risk factors were uterine scar and augmentation or epidural anaesthesia in a previous cesarean delivery. Acute abdominal pain in labour is the most frequent symptom for uterine rupture.

摘要

评估某单一三级转诊中心分娩期间完全性和部分性子宫破裂的发生率以及显著的风险因素、症状和围产期并发症。一项回顾性单中心研究纳入了2004年至2019年考纳斯围产期中心所有子宫破裂病例。数据来自当地医疗数据库,并辅以病历中的书面信息。我们纳入了45893名子宫完整的女性和5630名有子宫瘢痕的女性。其中5626名女性既往有剖宫产术后子宫瘢痕。诊断依据临床症状确定,当确诊为完全性或部分性子宫破裂(n = 35)时进行急诊剖宫产。排除在择期剖宫产时发现子宫破裂的无症状病例(n = 3)。对照组为研究期间在我们科室分娩的所有产妇(n = 51525)。结局指标为完全性(子宫壁各层包括浆膜层和胎膜层均撕裂)和部分性子宫破裂(子宫肌层缺损但浆膜层完整)这两种常见的子宫破裂症状。风险因素为与妊娠和分娩相关的参数。在研究期间的15年里,考纳斯围产期中心共发生51525例分娩。共记录到35例(0.06%)有症状的子宫破裂:22例为完全性破裂,13例为部分性破裂,导致每10000例分娩的发生率为6.8例。既往单次剖宫产术后子宫破裂的发生率为每10000例分娩44.4例。29例(83%)病例既往有剖宫产术后子宫瘢痕,4例(11%)既往有腹腔镜子宫肌瘤切除术,2例(6%)子宫无瘢痕。子宫破裂最显著的风险因素包括子宫瘢痕以及剖宫产术后子宫有瘢痕的患者使用催产素加强宫缩或硬膜外麻醉。最常见的临床症状是分娩时急性腹痛,共18例(51%)。未发生孕产妇死亡,6例围产儿在分娩期间死亡(17%),1例(2.8%)因子宫破裂行子宫切除术。完全性子宫破裂的新生儿死亡率达22%。平均失血量为1415 mL,4例(11%)患者需要输血。考纳斯围产期中心子宫破裂(完全性和不完全性)的发生率为每10000例分娩6.8例。在既往单次剖宫产术后子宫有瘢痕的病例中,子宫破裂的发生率更高,超过每10000例分娩44例。最显著的风险因素是子宫瘢痕以及既往剖宫产时使用催产素加强宫缩或硬膜外麻醉。分娩时急性腹痛是子宫破裂最常见的症状。

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