Dubey Sachin, Giovannini Roberto
Ichnos Sciences S.A., Chemin de la Combeta 5, La Chaux-de-Fonds, NE 2300, CH, Switzerland.
Ichnos Sciences S.A., Chemin de la Combeta 5, La Chaux-de-Fonds, NE 2300, CH, Switzerland.
Trends Biotechnol. 2021 Jun;39(6):546-549. doi: 10.1016/j.tibtech.2020.10.007. Epub 2020 Oct 30.
Most biopharmaceutical formulations use polysorbates: surfactants that are highly efficient but difficult to manage in terms of compositional variability, quality, and stability. Alternatives, such as poloxamers, albumin, and cyclodextrin, are becoming popular and are being explored for their potential to protect biopharmaceuticals against physical and mechanical stresses.
这类表面活性剂效率很高，但在成分变异性、质量和稳定性方面难以管控。泊洛沙姆、白蛋白和环糊精等替代物正变得越来越受欢迎，人们正在探索它们保护生物制药免受物理和机械应力影响的潜力。
