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Post-hoc analysis could give new life to the Alzheimer's drug aducanumab.

作者信息

Arnold Carrie

出版信息

Nat Med. 2020 Nov 2. doi: 10.1038/d41591-020-00031-z.

DOI:10.1038/d41591-020-00031-z
PMID:33139929
Abstract
摘要

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Post-hoc analysis could give new life to the Alzheimer's drug aducanumab.事后分析可能会给阿尔茨海默病药物阿杜卡努单抗带来新的生机。
Nat Med. 2020 Nov 2. doi: 10.1038/d41591-020-00031-z.
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Is Aducanumab treatment developed to prevent progression of Alzheimer's disease cost-effective in Turkey?在土耳其,用于预防阿尔茨海默病进展的阿杜卡努单抗治疗是否具有成本效益?
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Failure to demonstrate efficacy of aducanumab: An analysis of the EMERGE and ENGAGE trials as reported by Biogen, December 2019.未能证明 aducanumab 的疗效:Biogen 报告的 EMERGE 和 ENGAGE 试验分析,2019 年 12 月。
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Investigating Partially Discordant Results in Phase 3 Studies of Aducanumab.阿杜卡奴单抗3期研究中部分不一致结果的调查。
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Aducanumab, a Novel Anti-Amyloid Monoclonal Antibody, for the Treatment of Alzheimer's Disease: A Comprehensive Review.阿杜卡努单抗,一种新型抗淀粉样蛋白单克隆抗体,用于治疗阿尔茨海默病:综述
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Comparative efficacy of lithium and aducanumab for cognitive decline in patients with mild cognitive impairment or Alzheimer's disease: A systematic review and network meta-analysis.锂剂与 aducanumab 治疗轻度认知障碍或阿尔茨海默病患者认知衰退的疗效比较:系统评价和网络荟萃分析。
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8
Variation in Medicaid and commercial payer coverage of aducanumab for Alzheimer's disease.医疗补助计划和商业支付方对阿杜卡奴单抗治疗阿尔茨海默病的覆盖范围存在差异。
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Aducanumab: First Approval.阿杜卡奴单抗:首次获批
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Antibodies Raised Against an Aβ Oligomer Mimic Recognize Pathological Features in Alzheimer's Disease and Associated Amyloid-Disease Brain Tissue.针对Aβ寡聚体模拟物产生的抗体可识别阿尔茨海默病及相关淀粉样疾病脑组织中的病理特征。
ACS Cent Sci. 2023 Dec 21;10(1):104-121. doi: 10.1021/acscentsci.3c00592. eCollection 2024 Jan 24.
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ACU193: An Immunotherapeutic Poised to Test the Amyloid β Oligomer Hypothesis of Alzheimer's Disease.ACU193:一种有望验证阿尔茨海默病淀粉样β寡聚体假说的免疫疗法。
Front Neurosci. 2022 Apr 26;16:848215. doi: 10.3389/fnins.2022.848215. eCollection 2022.
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Restoration of Calmodulin-Like Skin Protein as Treatment for Alzheimer's Disease.
恢复类钙调蛋白样皮肤蛋白作为阿尔茨海默病的治疗方法。
Front Neurol. 2021 Oct 25;12:771856. doi: 10.3389/fneur.2021.771856. eCollection 2021.
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Machine learning of brain structural biomarkers for Alzheimer's disease (AD) diagnosis, prediction of disease progression, and amyloid beta deposition in the Japanese population.用于阿尔茨海默病(AD)诊断、疾病进展预测以及日本人群淀粉样β沉积的脑结构生物标志物的机器学习。
Alzheimers Dement (Amst). 2021 Oct 14;13(1):e12246. doi: 10.1002/dad2.12246. eCollection 2021.
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Dual Inhibitors of Amyloid-β and Tau Aggregation with Amyloid-β Disaggregating Properties: Extended , , and Kinetic Studies of Multifunctional Anti-Alzheimer's Agents.具有淀粉样β解聚特性的淀粉样β和 tau 聚集双重抑制剂:多功能抗阿尔茨海默病药物的扩展、、和动力学研究。
ACS Chem Neurosci. 2021 Jun 2;12(11):2057-2068. doi: 10.1021/acschemneuro.1c00235. Epub 2021 May 21.
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An "epitomic" analysis of the specificity of conformation-dependent, anti-Aß amyloid monoclonal antibodies.构象依赖性抗 Aβ淀粉样蛋白单克隆抗体特异性的“典范”分析。
J Biol Chem. 2021 Jan-Jun;296:100168. doi: 10.1074/jbc.RA120.015501. Epub 2020 Dec 14.