Department of Cardiology, Medical University of Lodz, Poland.
Department of Cardiac Rehabilitation, Bieganski Hospital, Lodz, Poland.
Cardiol J. 2022;29(6):948-953. doi: 10.5603/CJ.a2020.0139. Epub 2020 Nov 3.
A pilot study revealed a relationship between the results of flow mediated skin fluorescence (FMSF) and of ECG-Holter-based estimated apnea/hypopnea index (eAHI) in asymptomatic individuals. The aim of this study was to test whether the results of FMSF show a relationship with the eAHI in patients with coronary artery disease or aortic stenosis.
Twenty-one patients (12 coronary disease, 9 aortic stenosis) and 37 healthy volunteers were included. FMSF was assessed before, during and after the pressure occlusion of the brachial artery, using a prototype device allowing the quantification of skin fluorescence. The values of FMSF expressed as baseline (BASE), maximum (MAX), and minimum (MIN) were analyzed. The percentages of ischemic response (IR) and hyperemic response (HR) were calculated. The eAHI was assessed from night ECG-Holter recordings. Differences between the groups and the relationships between the parameters were analyzed statistically.
Mean ± standard deviation of BASE, MAX, MIN and IR were not significantly different in both groups (p > 0.05). HR was significantly lower in cardiac patients (14.7 ± 7.5 vs. 11.8 ± 5.1; p = 0.048), whose eAHI was significantly higher (11.0 ± 7.4 vs. 36.3 ± 16.5; p < 0.01). Negative correlation for MAX and eAHI was found in volunteers and patients: r = -0.38, p = 0.02 and r = -0.47, p = 0.03, respectively. In volunteers, HR had a negative correlation with eAHI: r = -0.34, p = 0.04.
This pioneer study confirms that FMSF can be used to detect the negative correlation between MAX fluorescence and eAHI not only among healthy volunteers, but also among cardiac patients with coronary artery disease or aortic stenosis.
一项初步研究显示，在无症状个体中，血流介导的皮肤荧光（FMSF）的结果与基于心电图-动态心电图的估计呼吸暂停/低通气指数（eAHI）之间存在关联。本研究旨在检验 FMSF 结果是否与冠心病或主动脉瓣狭窄患者的 eAHI 存在关联。
本研究共纳入 21 名患者（12 名冠心病，9 名主动脉瓣狭窄）和 37 名健康志愿者。使用一种允许量化皮肤荧光的原型设备，在肱动脉压力闭塞前后评估 FMSF。分析 FMSF 的基础值（BASE）、最大值（MAX）和最小值（MIN）。计算缺血反应（IR）和充血反应（HR）的百分比。通过夜间心电图-动态心电图记录评估 eAHI。统计分析组间差异和参数之间的关系。
两组间 BASE、MAX、MIN 和 IR 的平均值±标准差无显著差异（p>0.05）。心脏病患者的 HR 明显较低（14.7±7.5 比 11.8±5.1；p=0.048），其 eAHI 明显较高（11.0±7.4 比 36.3±16.5；p<0.01）。志愿者和患者的 MAX 与 eAHI 呈负相关：r=-0.38，p=0.02 和 r=-0.47，p=0.03。在志愿者中，HR 与 eAHI 呈负相关：r=-0.34，p=0.04。
本研究初步证实，FMSF 不仅可用于检测健康志愿者中 MAX 荧光与 eAHI 之间的负相关，还可用于检测冠心病或主动脉瓣狭窄患者中两者之间的负相关。
