Mayo Clinic, 4500 San Pablo Rd, Jacksonville, FL, 32224, USA.
Curr Cardiol Rep. 2019 Nov 9;21(11):137. doi: 10.1007/s11886-019-1228-3.
To review the clinical evidence for a relationship between obstructive sleep apnea and hypertension, arrhythmias, coronary artery disease, and congestive heart failure.
Current data show that obstructive sleep apnea is a risk for cardiovascular disease. Studies have linked untreated moderate to severe obstructive sleep apnea to hypertension, cardiac arrhythmias, coronary artery disease, and congestive heart failure. However, uncertainty regarding benefits of treatment of obstructive sleep apnea to reduce the risk of cardiovascular disease still exists. The issue of poor compliance has been an on-going limitation of CPAP trials. Evidence shows obstructive sleep apnea is a risk factor for cardiovascular disease but trials have yet to clarify if cardiovascular disease morbidity and mortality decreases with treatment of the apnea. Future treatment trials are needed to address the question of whether treatment decreases cardiovascular risk in patients with obstructive sleep apnea.
探讨阻塞性睡眠呼吸暂停与高血压、心律失常、冠状动脉疾病和充血性心力衰竭之间关系的临床证据。
目前的数据表明阻塞性睡眠呼吸暂停是心血管疾病的一个危险因素。研究表明,未经治疗的中重度阻塞性睡眠呼吸暂停与高血压、心律失常、冠状动脉疾病和充血性心力衰竭有关。然而,关于治疗阻塞性睡眠呼吸暂停以降低心血管疾病风险的益处仍存在不确定性。CPAP 试验中一直存在的一个限制因素是治疗依从性差。有证据表明阻塞性睡眠呼吸暂停是心血管疾病的一个危险因素,但试验尚未阐明治疗呼吸暂停是否会降低心血管疾病的发病率和死亡率。需要进行未来的治疗试验来解决治疗是否会降低阻塞性睡眠呼吸暂停患者心血管风险的问题。