Department of Neurosciences, Rehabilitation, Ophthalmology, Genetics and Maternal and Infantile Sciences (DINOGMI), University of Genova, Genova, Italy.
IRCCS Ospedale Policlinico San Martino, Genova, Italy.
J Peripher Nerv Syst. 2020 Dec;25(4):413-422. doi: 10.1111/jns.12421. Epub 2020 Nov 5.
The symptomatology of Charcot-Marie-Tooth (CMT) disease mainly involves the feet and the hands. To date, there is no consensus on how to evaluate hand function in CMT. The aim of this study is to correlate the data of the engineered glove Hand Test System (HTS) with specific tests and the CMT examination score (CMTES). We analyzed 45 patients with the diagnosis of CMT using HTS, which measures the hand dexterity by specific sequences performed at maximum velocity. We completed the evaluation with the CMTES, tripod pinch and hand grip strength tested by a dynamometer, thumb opposition test (TOT), and Sollerman Hand function test (SHFT), and we conducted a test-retest with 20 normal subjects. Finger tapping (FT) and index-medium-ring-little (IMRL) sequence showed a significant correlation with CMTES (FT: dominant hand (DH): P = .036; non-dominant hand (NDH): P = .033; IMRL: DH: P = .009; NDH: P = .046). TOT correlated with CMTES significantly in both hands (P < .0001). tripod pinch showed a statistically significant correlation with CMTES (DH: P = .002; NDH: P = .005). Correlation between the hand grip and CMTES was significant only in DH (DH: P = .002). SHFT had a significant correlation with the CMTES (DH: P = .002). Test-retest showed a good reliability. HTS parameters correlate with CMTES confirming that this tool is sensitive to the hand deficits. In conclusion, we can state that HTS is a good, simple to use, and objective instrument to evaluate the hand function of CMT patients, but more studies on responsiveness and sensitivity are needed.
Charcot-Marie-Tooth (CMT) 病的症状主要涉及脚和手。迄今为止，对于如何评估 CMT 患者的手部功能尚无共识。本研究旨在将工程手套 Hand Test System (HTS) 的数据与特定测试和 CMT 检查评分 (CMTES) 相关联。我们分析了 45 名 CMT 患者的 HTS 数据，该系统通过最大速度下进行的特定序列来测量手的灵巧度。我们使用 CMTES、测力计测试的三指捏力和手握力、拇指对掌测试 (TOT) 和 Sollerman 手部功能测试 (SHFT) 完成评估，并对 20 名正常受试者进行了测试-重测。手指叩击 (FT) 和食指-中指-环指-小指 (IMRL) 序列与 CMTES 显著相关 (FT：优势手 (DH)：P =.036；非优势手 (NDH)：P =.033；IMRL：DH：P =.009；NDH：P =.046)。TOT 在双手与 CMTES 显著相关 (P < .0001)。三指捏力与 CMTES 呈统计学显著相关 (DH：P =.002；NDH：P =.005)。仅在 DH 中，手握力与 CMTES 呈显著相关 (DH：P =.002)。SHFT 与 CMTES 有显著相关性 (DH：P =.002)。测试-重测显示出良好的可靠性。HTS 参数与 CMTES 相关，证实该工具对手部缺陷敏感。总之，我们可以说 HTS 是一种简单易用、客观的工具，可以评估 CMT 患者的手部功能，但需要更多的响应性和敏感性研究。
