Structural Biology and Bioinformatics Division, CSIR-Indian Institute of Chemical Biology, Kolkata 700 032, WB India.
ACS Chem Neurosci. 2020 Nov 18;11(22):3701-3703. doi: 10.1021/acschemneuro.0c00661. Epub 2020 Nov 3.
Cell entry, the fundamental step in cross-species transmission of SARS-CoV-2 (severe acute respiratory syndrome coronavirus 2), is initiated by the recognition of the host cell angiotensin-converting enzyme-2 (ACE2) receptor by the receptor-binding domain (RBD) of the spike protein of SARS-CoV-2. To date, several peptides have been proposed against SARS-CoV-2 both as inhibitor agents or as detection tools that can also be attached to the surfaces of nanoparticle carriers. But owing to their natural amino acid sequences, such peptides cannot be considered as efficient therapeutic candidates from a biostability point of view. This discussion demonstrates the design strategy of synthetic nonprotein amino acid substituted peptides with enhanced biostability and binding affinity, the implication of which can make those peptides potential therapeutic agents for inhibition and simple detection tools.
细胞进入是 SARS-CoV-2（严重急性呼吸系统综合症冠状病毒 2）跨物种传播的基本步骤，由宿主细胞血管紧张素转换酶 2（ACE2）受体被 SARS-CoV-2 刺突蛋白受体结合域（RBD）识别而引发。迄今为止，已经提出了几种针对 SARS-CoV-2 的肽类，它们既可以作为抑制剂，也可以作为检测工具，还可以附着在纳米颗粒载体的表面。但是，由于其天然氨基酸序列，从生物稳定性的角度来看，这些肽类不能被视为有效的治疗候选物。本讨论展示了设计具有增强生物稳定性和结合亲和力的合成非蛋白氨基酸取代肽的策略，这意味着这些肽类可能成为抑制和简单检测工具的潜在治疗剂。
