Department of Obstetrics and Gynecology, Faculty of Medicine, Fayoum University, Fayoum, Egypt.
Department of Family Medicine, Sebasticook Valley Hospital, Pittsfield, ME, USA.
Hum Fertil (Camb). 2022 Jul;25(3):422-429. doi: 10.1080/14647273.2020.1842915. Epub 2020 Nov 3.
This paper reports a systematic review and meta-analysis of the effectiveness of hyoscine-N-butylbromide (HBB) administration in hysterosalpingography (HSG). Four electronic databases were searched for randomised controlled trials (RCTs) that compared HBB versus placebo or no intervention in infertile women undergoing HSG. Pain during and after HSG and different adverse events including nausea, vomiting, and dizziness were evaluated. Three RCTs with 335 patients were included. The analysis showed HBB was significantly effective in reducing pain during and after HSG (MD = -0.76 mm, 95% CI [-1.35, -0.17], = 0.01) and (MD = -0.81 mm, 95% CI [-1.07, -0.56], < 0.001), respectively. There were no significant differences in adverse events between HBB and control groups. The methodological evidence quality was high as evaluated by GRADEpro. In conclusion, this review provides good evidence that prior administration of HBB is effective in reducing induced pain during and after HSG with tolerable side effects.
本文报告了一项关于氢溴酸莨菪碱（HBB）在子宫输卵管造影术（HSG）中有效性的系统评价和荟萃分析。检索了四个电子数据库，以寻找比较 HBB 与安慰剂或无干预措施在接受 HSG 的不孕女性中的随机对照试验（RCT）。评估了 HSG 期间和之后的疼痛以及包括恶心、呕吐和头晕在内的不同不良事件。纳入了三项涉及 335 名患者的 RCT。分析表明，HBB 在减轻 HSG 期间和之后的疼痛方面具有显著效果（MD = -0.76 mm，95%CI [-1.35，-0.17]， = 0.01）和（MD = -0.81 mm，95%CI [-1.07，-0.56]， < 0.001）。HBB 和对照组之间在不良事件方面没有显著差异。根据 GRADEpro 评估，方法学证据质量较高。总之，本综述提供了良好的证据，表明在 HSG 前给予 HBB 可有效减轻诱导性疼痛，且副作用可耐受。
