Hillidge C J
Department of Medical Sciences, College of Veterinary Medicine, University of Florida, Gainesville 32610.
Vet Microbiol. 1987 Aug;14(3):337-42. doi: 10.1016/0378-1135(87)90121-0.
The selection of lipid-soluble antibiotics capable of intracellular penetration is considered critical for the successful treatment of Rhodococcus equi pneumonia and lung abscesses in foals. Two such antibiotics: erythromycin (25 mg kg-1, three times daily) and rifampin (5 mg kg-1 twice daily) have been used in combination for this purpose at the University of Florida since 1981. Positive evidence of R. equi was present on culture of tracheal aspirates in 57 foals, most of which exhibited radiographic evidence of extensive lung abscessation. The duration of therapy ranged from 4 to 9 weeks. Mild diarrhea was sometimes noted, but was never severe enough to require the termination of therapy. No other adverse side effects were apparent. Judged by a return of chest radiographs and hematologic parameters to normal, 50 of the 57 foals were considered to have recovered from the disease; a success rate of 88%.
对于成功治疗幼驹马红球菌肺炎和肺脓肿而言，选择能够穿透细胞的脂溶性抗生素被认为至关重要。自1981年以来，佛罗里达大学一直将两种此类抗生素联合使用：红霉素（25毫克/千克，每日三次）和利福平（5毫克/千克，每日两次）。在57匹幼驹的气管吸出物培养物中发现了马红球菌阳性证据，其中大多数呈现出广泛肺脓肿的影像学证据。治疗持续时间为4至9周。有时会注意到轻度腹泻，但从未严重到需要终止治疗。未出现其他明显的不良副作用。根据胸部X光片和血液学参数恢复正常判断，57匹幼驹中有50匹被认为已从疾病中康复；成功率为88%。
